DegronMD - Q9BW71(HIRIP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A35G	TCGA-22-5489	LUSC	TCGA	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0556
p.A35G	DO26480	LUSC	ICGC	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0556
p.M7T	TCGA-5R-AA1D	LIHC	TCGA	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation blocking phosphorylation signal	0.5
p.M7T	DO219547	LIHC	ICGC	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation blocking phosphorylation signal	0.5
p.P19Q	TCGA-86-7701	LUAD	TCGA	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.5924
p.P19Q	DO24441	LUAD	ICGC	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.5924
p.D20G	TCGA-F4-6806	COAD	TCGA	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.6087
p.D20G	DO8296	COAD	ICGC	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.6087
p.S13G	TCGA-VQ-A924	STAD	TCGA	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.2222
p.S13G	DO51795	STAD	ICGC	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.2222
p.T23K	DO228952	LICA	ICGC	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.6195
p.Q8L	DO229253	THCA	ICGC	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.H26Y	SIDM00364	B-Lymphoblastic Leukemia	GDSC	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.3056
p.H26Y	ACH-002059	Leukemia	CCLE	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.3056
p.H26Y	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.3056
p.R12S	SIDM00619	Thyroid Gland Carcinoma	GDSC	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.1944
p.R12S	ACH-002397	Thyroid Cancer	CCLE	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.1944
p.R12S	KMH-2	thyroid	COSMIC	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.1944
p.G17C	ACH-000961	Endometrial/Uterine Cancer	CCLE	GRPDLSTLT	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.6489

Kaplan plot for HIRIP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HIRIP3

UniProt ID: Q9BW71

Entrez ID: 8479

Protein name: HIRA-interacting protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HIRIP3 in