DegronMD

Uniprot ID: Q9BW71

Source protein: HIRA-interacting protein 3

Source gene: HIRIP3

Class: DEG_APCC_DBOX_1

Location: 17:25

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6889

ASA_SCORE: 65.6889

COIL: 0.6637

CONS_SCORE: 0.4681

DSS_SCORE: 0.3195

HELIX: 0.3282

FCONS_SCORE: 1.1473

RIG_SCORE: 0.7088

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A35G	TCGA-22-5489	LUSC	TCGA	GRPDLSTLT	DEG_APCC_DBOX_1	0.0556
p.A35G	DO26480	LUSC	ICGC	GRPDLSTLT	DEG_APCC_DBOX_1	0.0556
p.M7T	TCGA-5R-AA1D	LIHC	TCGA	GRPDLSTLT	DEG_APCC_DBOX_1	0.5
p.M7T	DO219547	LIHC	ICGC	GRPDLSTLT	DEG_APCC_DBOX_1	0.5
p.P19Q	TCGA-86-7701	LUAD	TCGA	GRPDLSTLT	DEG_APCC_DBOX_1	0.5924
p.P19Q	DO24441	LUAD	ICGC	GRPDLSTLT	DEG_APCC_DBOX_1	0.5924
p.D20G	TCGA-F4-6806	COAD	TCGA	GRPDLSTLT	DEG_APCC_DBOX_1	0.6087
p.D20G	DO8296	COAD	ICGC	GRPDLSTLT	DEG_APCC_DBOX_1	0.6087
p.S13G	TCGA-VQ-A924	STAD	TCGA	GRPDLSTLT	DEG_APCC_DBOX_1	0.2222
p.S13G	DO51795	STAD	ICGC	GRPDLSTLT	DEG_APCC_DBOX_1	0.2222
p.T23K	DO228952	LICA	ICGC	GRPDLSTLT	DEG_APCC_DBOX_1	0.6195
p.Q8L	DO229253	THCA	ICGC	GRPDLSTLT	DEG_APCC_DBOX_1	0.0833
p.H26Y	SIDM00364	B-Lymphoblastic Leukemia	GDSC	GRPDLSTLT	DEG_APCC_DBOX_1	0.3056
p.H26Y	ACH-002059	Leukemia	CCLE	GRPDLSTLT	DEG_APCC_DBOX_1	0.3056
p.H26Y	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	GRPDLSTLT	DEG_APCC_DBOX_1	0.3056
p.R12S	SIDM00619	Thyroid Gland Carcinoma	GDSC	GRPDLSTLT	DEG_APCC_DBOX_1	0.1944
p.R12S	ACH-002397	Thyroid Cancer	CCLE	GRPDLSTLT	DEG_APCC_DBOX_1	0.1944
p.R12S	KMH-2	thyroid	COSMIC	GRPDLSTLT	DEG_APCC_DBOX_1	0.1944
p.G17C	ACH-000961	Endometrial/Uterine Cancer	CCLE	GRPDLSTLT	DEG_APCC_DBOX_1	0.6489

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BW71	HIRA-interacting protein 3	DEG_APCC_DBOX_1	17:25	GRPDLSTLT	APC,CDC20,FZR1	0.6889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons