DegronMD - Q9BWD1(ACAT2)

ACAT2

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D219H	TCGA-CI-6619	READ	TCGA	TRKGLIEVK	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.2778
p.F221C	TCGA-D1-A16X	UCEC	TCGA	TRKGLIEVK	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.2222
p.R210K	TCGA-IG-A3Y9	ESCA	TCGA	TRKGLIEVK	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.7237
p.L213V	DO1076	BRCA	ICGC	TRKGLIEVK	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.6765
p.A221S	DO229009	LICA	ICGC	TRKGLIEVK	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.2222
p.D208H	DO23010	LIHC	ICGC	TRKGLIEVK	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.3056
p.A224V	DO44919	LIHC	ICGC	TRKGLIEVK	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.1389
p.D208V	DO231538	LINC	ICGC	TRKGLIEVK	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.3056
p.H226R	DO52674	MALY	ICGC	TRKGLIEVK	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.0833
p.R223C	SIDM00217	Colorectal Carcinoma	GDSC	TRKGLIEVK	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.1667
p.R223C	ACH-000999	Colon/Colorectal Cancer	CCLE	TRKGLIEVK	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.1667
p.R223C	SNU-1040	large intestine	COSMIC	TRKGLIEVK	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.1667
p.K217E	ACH-001164	Sarcoma	CCLE	TRKGLIEVK	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.591

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*NOTE: the Kaplan plots were collected from OncoLnc