DegronMD

Uniprot ID: Q9BWD1

Source protein: Acetyl-CoA acetyltransferase, cytosolic

Source gene: ACAT2

Class: DEG_APCC_DBOX_1

Location: 209:217

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8351

ASA_SCORE: 82.3333

COIL: 0.4793

CONS_SCORE: 0.4056

DSS_SCORE: 0.301

HELIX: 0.0171

FCONS_SCORE: 0.732

RIG_SCORE: 0.7945

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D219H	TCGA-CI-6619	READ	TCGA	TRKGLIEVK	DEG_APCC_DBOX_1	0.2778
p.F221C	TCGA-D1-A16X	UCEC	TCGA	TRKGLIEVK	DEG_APCC_DBOX_1	0.2222
p.R210K	TCGA-IG-A3Y9	ESCA	TCGA	TRKGLIEVK	DEG_APCC_DBOX_1	0.7237
p.L213V	DO1076	BRCA	ICGC	TRKGLIEVK	DEG_APCC_DBOX_1	0.6765
p.A221S	DO229009	LICA	ICGC	TRKGLIEVK	DEG_APCC_DBOX_1	0.2222
p.D208H	DO23010	LIHC	ICGC	TRKGLIEVK	DEG_APCC_DBOX_1	0.3056
p.A224V	DO44919	LIHC	ICGC	TRKGLIEVK	DEG_APCC_DBOX_1	0.1389
p.D208V	DO231538	LINC	ICGC	TRKGLIEVK	DEG_APCC_DBOX_1	0.3056
p.H226R	DO52674	MALY	ICGC	TRKGLIEVK	DEG_APCC_DBOX_1	0.0833
p.R223C	SIDM00217	Colorectal Carcinoma	GDSC	TRKGLIEVK	DEG_APCC_DBOX_1	0.1667
p.R223C	ACH-000999	Colon/Colorectal Cancer	CCLE	TRKGLIEVK	DEG_APCC_DBOX_1	0.1667
p.R223C	SNU-1040	large_intestine	COSMIC	TRKGLIEVK	DEG_APCC_DBOX_1	0.1667
p.K217E	ACH-001164	Sarcoma	CCLE	TRKGLIEVK	DEG_APCC_DBOX_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BWD1	Acetyl-CoA acetyltransferase, cytosolic	DEG_APCC_DBOX_1	209:217	TRKGLIEVK	APC,CDC20,FZR1	0.8351	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons