DegronMD - Q9BX84(TRPM6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1310V	TCGA-19-5956	GBM	TCGA	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1667
p.R1297K	TCGA-EE-A17X	SKCM	TCGA	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation altering degron motif	0.7237
p.R1314K	TCGA-EW-A1J5	BRCA	TCGA	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.0556
p.R1294K	TCGA-FS-A1ZF	SKCM	TCGA	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.2778
p.R1309K	DO6144	BRCA	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1944
p.L1295R	DO50374	ESAD	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.3056
p.L1296H	DO234303	ESAD	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation altering degron motif	0.7313
p.A1305V	DO13863	GBM	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.3056
p.Q1291H	DO50819	LIRI	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1944
p.R1314W	DO25498	LUAD	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.0556
p.R1292K	DO222708	MELA	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.2222
p.R1292K	DO37931	SKCM	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.2222
p.E1313K	DO48702	SKCM	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.0833
p.R1289K	DO38039	SKCM	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1389
p.H1291Y	SIDM00373	Endometrial Carcinoma	GDSC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1944
p.H1291Y	ACH-000974	Endometrial/Uterine Cancer	CCLE	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1944
p.H1291Y	ACH-002026	Endometrial/Uterine Cancer	CCLE	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1944
p.H1291Y	SNG-M	endometrium	COSMIC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1944
p.T1311I	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1389
p.T1311I	NCI-H1581	lung	COSMIC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1389
p.N1305H	SIDM00118	Colorectal Carcinoma	GDSC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.3056
p.N1305H	ACH-001081	Colon/Colorectal Cancer	CCLE	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.3056
p.N1305H	HCC2998	large intestine	COSMIC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.3056
p.H1286Y	SNG-M	endometrium	COSMIC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.0556
p.T1306I	NCI-H1581	lung	COSMIC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.2778
p.N1300H	HCC2998	large intestine	COSMIC	QRGALLEIT	DEG_APCC_DBOX_1	1296:1304	Mutation altering degron motif	0.7423

Kaplan plot for TRPM6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRPM6

UniProt ID: Q9BX84

Entrez ID: 140803

Protein name: Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRPM6 in