DegronMD

Uniprot ID: Q9BX84

Source protein: Transient receptor potential cation channel subfamily M member 6

Source gene: TRPM6

Class: DEG_APCC_DBOX_1

Location: 1296:1304

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7531

ASA_SCORE: 89.8

COIL: 0.6762

CONS_SCORE: 0.1746

DSS_SCORE: 0.5808

HELIX: 0.1723

FCONS_SCORE: 0.8981

RIG_SCORE: 0.7324

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1310V	TCGA-19-5956	GBM	TCGA	QRGALLEIT	DEG_APCC_DBOX_1	0.1667
p.R1297K	TCGA-EE-A17X	SKCM	TCGA	QRGALLEIT	DEG_APCC_DBOX_1	0.7237
p.R1314K	TCGA-EW-A1J5	BRCA	TCGA	QRGALLEIT	DEG_APCC_DBOX_1	0.0556
p.R1294K	TCGA-FS-A1ZF	SKCM	TCGA	QRGALLEIT	DEG_APCC_DBOX_1	0.2778
p.R1309K	DO6144	BRCA	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	0.1944
p.L1295R	DO50374	ESAD	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	0.3056
p.L1296H	DO234303	ESAD	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	0.7313
p.A1305V	DO13863	GBM	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	0.3056
p.Q1291H	DO50819	LIRI	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	0.1944
p.R1314W	DO25498	LUAD	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	0.0556
p.R1292K	DO222708	MELA	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	0.2222
p.R1292K	DO37931	SKCM	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	0.2222
p.E1313K	DO48702	SKCM	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	0.0833
p.R1289K	DO38039	SKCM	ICGC	QRGALLEIT	DEG_APCC_DBOX_1	0.1389
p.H1291Y	SIDM00373	Endometrial Carcinoma	GDSC	QRGALLEIT	DEG_APCC_DBOX_1	0.1944
p.H1291Y	ACH-000974	Endometrial/Uterine Cancer	CCLE	QRGALLEIT	DEG_APCC_DBOX_1	0.1944
p.H1291Y	ACH-002026	Endometrial/Uterine Cancer	CCLE	QRGALLEIT	DEG_APCC_DBOX_1	0.1944
p.H1291Y	SNG-M	endometrium	COSMIC	QRGALLEIT	DEG_APCC_DBOX_1	0.1944
p.T1311I	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	QRGALLEIT	DEG_APCC_DBOX_1	0.1389
p.T1311I	NCI-H1581	lung	COSMIC	QRGALLEIT	DEG_APCC_DBOX_1	0.1389
p.N1305H	SIDM00118	Colorectal Carcinoma	GDSC	QRGALLEIT	DEG_APCC_DBOX_1	0.3056
p.N1305H	ACH-001081	Colon/Colorectal Cancer	CCLE	QRGALLEIT	DEG_APCC_DBOX_1	0.3056
p.N1305H	HCC2998	large_intestine	COSMIC	QRGALLEIT	DEG_APCC_DBOX_1	0.3056
p.H1286Y	SNG-M	endometrium	COSMIC	QRGALLEIT	DEG_APCC_DBOX_1	0.0556
p.T1306I	NCI-H1581	lung	COSMIC	QRGALLEIT	DEG_APCC_DBOX_1	0.2778
p.N1300H	HCC2998	large_intestine	COSMIC	QRGALLEIT	DEG_APCC_DBOX_1	0.7423

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRGALLEIT

Degron related mutations and impact score

Drug responses associated with TRPM6 mutations

All proteins holding degron of QRGALLEIT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BX84	Transient receptor potential cation channel subfamily M member 6	DEG_APCC_DBOX_1	1296:1304	QRGALLEIT	APC,CDC20,FZR1	0.7531	More...