DegronMD - Q9BXB7(SPATA16)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R419I	TCGA-19-5956	GBM	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.0833
p.R419I	DO13863	GBM	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.0833
p.L417V	TCGA-37-3792	LUSC	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1389
p.L417V	DO27192	LUSC	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1389
p.H411R	TCGA-49-4507	LUAD	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.3056
p.H411R	DO25727	LUAD	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.3056
p.T418N	TCGA-56-A62T	LUSC	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1111
p.T418N	DO219144	LUSC	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1111
p.F408C	TCGA-A6-2686	COAD	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation altering degron motif	0.7108
p.F408C	DO7828	COAD	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation altering degron motif	0.7108
p.F408Y	TCGA-DD-A4NK	LIHC	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation altering degron motif	0.6417
p.F408Y	DO44882	LIHC	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation altering degron motif	0.6417
p.E410K	TCGA-ER-A42L	SKCM	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation altering degron motif	0.7022
p.E410K	DO223910	SKCM	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation altering degron motif	0.7022
p.F396V	TCGA-EY-A1GI	UCEC	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1111
p.F396V	DO41211	UCEC	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1111
p.K395N	TCGA-FB-A5VM	PAAD	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation substituting flanking lysine	0.1944
p.K395N	DO49401	PAAD	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation substituting flanking lysine	0.1944
p.P414L	TCGA-FS-A1ZA	SKCM	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.2222
p.P414L	DO37551	SKCM	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.2222
p.G394R	TCGA-GN-A8LK	SKCM	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.0556
p.G394R	DO51259	SKCM	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.0556
p.G416S	DO225072	BRCA	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1667
p.G416S	DO227701	BRCA	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1667
p.G416S	SIDM01020	Plasma Cell Myeloma	GDSC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1667
p.G416S	SIDM01040	Ovarian Carcinoma	GDSC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1667
p.G416S	SIDM00589	Oral Cavity Carcinoma	GDSC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1667
p.G416S	ACH-000380	Myeloma	CCLE	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1667
p.G416S	ACH-000574	Ovarian Cancer	CCLE	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1667
p.G416S	ACH-000778	Head and Neck Cancer	CCLE	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1667
p.G416S	ACH-002038	Ovarian Cancer	CCLE	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1667
p.G416S	FU-OV-1	ovary	COSMIC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1667
p.G416S	HSC-3	upper aerodigestive tract	COSMIC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1667
p.G416S	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1667
p.S402R	DO228971	LICA	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.2778
p.H411N	DO229025	LICA	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.3056
p.G394E	DO220851	MELA	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.0556
p.G394E	DO222494	MELA	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.0556
p.G394E	DO218860	SKCA	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.0556
p.P406L	DO228794	PRAD	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation altering degron motif	0.6471
p.E398G	SIDM02059	Colorectal Carcinoma	GDSC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1667
p.E420D	SIDM00499	Prostate Carcinoma	GDSC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.0556
p.E398K	ACH-001568	Skin Cancer	CCLE	KLPIFTE	LIG_APCC_ABBAyCdc20_2	404:410	Mutation rewiring degron network	0.1667

Kaplan plot for SPATA16 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPATA16

UniProt ID: Q9BXB7

Entrez ID: 83893

Protein name: Spermatogenesis-associated protein 16 (Testis development protein NYD-SP12)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPATA16 in