DegronMD

Uniprot ID: Q9BXB7

Source protein: Spermatogenesis-associated protein 16

Source gene: SPATA16

Class: LIG_APCC_ABBAyCdc20_2

Location: 404:410

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7239

ASA_SCORE: 75.9286

COIL: 0.6884

CONS_SCORE: 0.6334

DSS_SCORE: 0.3239

HELIX: 0.0647

FCONS_SCORE: 1.0454

RIG_SCORE: 0.7663

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R419I	TCGA-19-5956	GBM	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R419I	DO13863	GBM	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.L417V	TCGA-37-3792	LUSC	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1389
p.L417V	DO27192	LUSC	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1389
p.H411R	TCGA-49-4507	LUAD	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.3056
p.H411R	DO25727	LUAD	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.3056
p.T418N	TCGA-56-A62T	LUSC	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1111
p.T418N	DO219144	LUSC	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1111
p.F408C	TCGA-A6-2686	COAD	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.7108
p.F408C	DO7828	COAD	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.7108
p.F408Y	TCGA-DD-A4NK	LIHC	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.6417
p.F408Y	DO44882	LIHC	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.6417
p.E410K	TCGA-ER-A42L	SKCM	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E410K	DO223910	SKCM	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.7022
p.F396V	TCGA-EY-A1GI	UCEC	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1111
p.F396V	DO41211	UCEC	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1111
p.K395N	TCGA-FB-A5VM	PAAD	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K395N	DO49401	PAAD	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P414L	TCGA-FS-A1ZA	SKCM	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P414L	DO37551	SKCM	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G394R	TCGA-GN-A8LK	SKCM	TCGA	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.G394R	DO51259	SKCM	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.G416S	DO225072	BRCA	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G416S	DO227701	BRCA	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G416S	SIDM01020	Plasma Cell Myeloma	GDSC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G416S	SIDM01040	Ovarian Carcinoma	GDSC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G416S	SIDM00589	Oral Cavity Carcinoma	GDSC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G416S	ACH-000380	Myeloma	CCLE	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G416S	ACH-000574	Ovarian Cancer	CCLE	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G416S	ACH-000778	Head and Neck Cancer	CCLE	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G416S	ACH-002038	Ovarian Cancer	CCLE	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G416S	FU-OV-1	ovary	COSMIC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G416S	HSC-3	upper_aerodigestive_tract	COSMIC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G416S	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S402R	DO228971	LICA	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.2778
p.H411N	DO229025	LICA	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.3056
p.G394E	DO220851	MELA	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.G394E	DO222494	MELA	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.G394E	DO218860	SKCA	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P406L	DO228794	PRAD	ICGC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.6471
p.E398G	SIDM02059	Colorectal Carcinoma	GDSC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E420D	SIDM00499	Prostate Carcinoma	GDSC	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E398K	ACH-001568	Skin Cancer	CCLE	KLPIFTE	LIG_APCC_ABBAyCdc20_2	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KLPIFTE

Degron related mutations and impact score

Drug responses associated with SPATA16 mutations

All proteins holding degron of KLPIFTE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXB7	Spermatogenesis-associated protein 16	LIG_APCC_ABBAyCdc20_2	404:410	KLPIFTE	APC,CDC20,FZR1	0.7239	More...