DegronMD - Q9BXI3(NT5C1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G341C	TCGA-44-7660	LUAD	TCGA	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.0556
p.G341C	DO23834	LUAD	ICGC	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.0556
p.V343E	TCGA-62-A46O	LUAD	TCGA	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.1111
p.V343E	DO26240	LUAD	ICGC	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.1111
p.R357W	TCGA-AX-A05Z	UCEC	TCGA	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation altering degron motif	0.7523
p.R357W	DO40884	UCEC	ICGC	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation altering degron motif	0.7523
p.A345T	DO230346	COCA	ICGC	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.1667
p.A344S	DO223060	ESCA	ICGC	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.1389
p.A344S	DO223080	ESCA	ICGC	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.1389
p.A344S	ACH-002388	Skin Cancer	CCLE	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.1389
p.R356Q	SIDM00917	Acute Myeloid Leukemia	GDSC	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation altering degron motif	0.6218
p.R356Q	SIDM01191	Osteosarcoma	GDSC	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation altering degron motif	0.6218
p.R356Q	CESS	haematopoietic and lymphoid tissue	COSMIC	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation altering degron motif	0.6218
p.R356Q	U-2-OS	bone	COSMIC	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation altering degron motif	0.6218
p.A352V	SIDM00148	Breast Carcinoma	GDSC	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation altering degron motif	0.5825
p.A352V	ACH-000019	Breast Cancer	CCLE	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation altering degron motif	0.5825
p.A352V	ACH-000028	Breast Cancer	CCLE	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation altering degron motif	0.5825
p.A352V	ACH-001369	Ovarian Cancer	CCLE	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation altering degron motif	0.5825
p.A352V	MCF7	breast	COSMIC	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation altering degron motif	0.5825
p.A344V	SIDM00241	Breast Carcinoma	GDSC	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.1389
p.A344V	ACH-002179	Breast Cancer	CCLE	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.1389
p.A344V	OCUB-M	breast	COSMIC	VAQTPRRT	DEG_SCF_FBW7_1	351:358	Mutation rewiring degron network	0.1389

Kaplan plot for NT5C1A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NT5C1A

UniProt ID: Q9BXI3

Entrez ID: 84618

Protein name: Cytosolic 5'-nucleotidase 1A (cN1A) (EC 3.1.3.5) (Cytosolic 5'-nucleotidase IA) (cN-I) (cN-IA)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NT5C1A in