DegronMD

Uniprot ID: Q9BXI3

Source protein: Cytosolic 5'-nucleotidase 1A

Source gene: NT5C1A

Class: DEG_SCF_FBW7_1

Location: 351:358

E3 ligase: FBXW7

DEGRON score: 0.815

ASA_SCORE: 100.5

COIL: 0.7758

CONS_SCORE: 0.3601

DSS_SCORE: 0.5329

HELIX: 0.0436

FCONS_SCORE: 0.7131

RIG_SCORE: 0.7156

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G341C	TCGA-44-7660	LUAD	TCGA	VAQTPRRT	DEG_SCF_FBW7_1	0.0556
p.G341C	DO23834	LUAD	ICGC	VAQTPRRT	DEG_SCF_FBW7_1	0.0556
p.V343E	TCGA-62-A46O	LUAD	TCGA	VAQTPRRT	DEG_SCF_FBW7_1	0.1111
p.V343E	DO26240	LUAD	ICGC	VAQTPRRT	DEG_SCF_FBW7_1	0.1111
p.R357W	TCGA-AX-A05Z	UCEC	TCGA	VAQTPRRT	DEG_SCF_FBW7_1	0.7523
p.R357W	DO40884	UCEC	ICGC	VAQTPRRT	DEG_SCF_FBW7_1	0.7523
p.A345T	DO230346	COCA	ICGC	VAQTPRRT	DEG_SCF_FBW7_1	0.1667
p.A344S	DO223060	ESCA	ICGC	VAQTPRRT	DEG_SCF_FBW7_1	0.1389
p.A344S	DO223080	ESCA	ICGC	VAQTPRRT	DEG_SCF_FBW7_1	0.1389
p.A344S	ACH-002388	Skin Cancer	CCLE	VAQTPRRT	DEG_SCF_FBW7_1	0.1389
p.R356Q	SIDM00917	Acute Myeloid Leukemia	GDSC	VAQTPRRT	DEG_SCF_FBW7_1	0.6218
p.R356Q	SIDM01191	Osteosarcoma	GDSC	VAQTPRRT	DEG_SCF_FBW7_1	0.6218
p.R356Q	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	VAQTPRRT	DEG_SCF_FBW7_1	0.6218
p.R356Q	U-2-OS	bone	COSMIC	VAQTPRRT	DEG_SCF_FBW7_1	0.6218
p.A352V	SIDM00148	Breast Carcinoma	GDSC	VAQTPRRT	DEG_SCF_FBW7_1	0.5825
p.A352V	ACH-000019	Breast Cancer	CCLE	VAQTPRRT	DEG_SCF_FBW7_1	0.5825
p.A352V	ACH-000028	Breast Cancer	CCLE	VAQTPRRT	DEG_SCF_FBW7_1	0.5825
p.A352V	ACH-001369	Ovarian Cancer	CCLE	VAQTPRRT	DEG_SCF_FBW7_1	0.5825
p.A352V	MCF7	breast	COSMIC	VAQTPRRT	DEG_SCF_FBW7_1	0.5825
p.A344V	SIDM00241	Breast Carcinoma	GDSC	VAQTPRRT	DEG_SCF_FBW7_1	0.1389
p.A344V	ACH-002179	Breast Cancer	CCLE	VAQTPRRT	DEG_SCF_FBW7_1	0.1389
p.A344V	OCUB-M	breast	COSMIC	VAQTPRRT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXI3	Cytosolic 5'-nucleotidase 1A	DEG_SCF_FBW7_1	351:358	VAQTPRRT	FBXW7	0.815	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons