DegronMD - Q9BXN2(CLEC7A)

GO - Biological processes (BP): antifungal innate immune response [GO:0061760]; carbohydrate mediated signaling [GO:0009756]; cell activation [GO:0001775]; cell recognition [GO:0008037]; cellular response to molecule of fungal origin [GO:0071226]; defense response to protozoan [GO:0042832]; detection of fungus [GO:0016046]; detection of molecule of fungal origin [GO:0032491]; detection of yeast [GO:0001879]; inflammatory response [GO:0006954]; leukocyte activation involved in immune response [GO:0002366]; phagocytosis, recognition [GO:0006910]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell maturation [GO:1903431]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of gene expression [GO:0010628]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of killing of cells of another organism [GO:0051712]; positive regulation of lymphocyte activation [GO:0051251]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of respiratory burst [GO:0060267]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of wound healing [GO:0090303]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; response to yeast [GO:0001878]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell activation [GO:0042110] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E90D	TCGA-2Y-A9H5	LIHC	TCGA	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation altering degron motif	0.6758
p.E90D	DO219529	LIHC	ICGC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation altering degron motif	0.6758
p.L85I	TCGA-B5-A0JY	UCEC	TCGA	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.25
p.L85I	TCGA-EO-A3B0	UCEC	TCGA	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.25
p.L85I	DO219773	UCEC	ICGC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.25
p.L85I	DO43041	UCEC	ICGC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.25
p.E84K	DO44045	BLCA	ICGC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.2222
p.C96G	DO225293	BRCA	ICGC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.2222
p.C96G	DO227475	BRCA	ICGC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.2222
p.F91C	DO225395	BRCA	ICGC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation altering degron motif	0.7108
p.S81R	DO223732	CESC	ICGC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.1389
p.I98L	DO222762	COCA	ICGC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.1667
p.S94Y	DO222846	COCA	ICGC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.2778
p.R87K	DO233168	GACA	ICGC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.3056
p.S81N	DO22333	LGG	ICGC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.1389
p.P96T	DO229041	LICA	ICGC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.2222
p.H92Q	DO229009	LICA	ICGC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation altering degron motif	0.647
p.I97M	DO45151	LIRI	ICGC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.1944
p.G86R	DO220899	MELA	ICGC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.2778
p.G86R	DO229459	SKCA	ICGC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.2778
p.S94F	DO50287	SKCM	ICGC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.2778
p.S99Y	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.1389
p.S91P	Capan-2	pancreas	COSMIC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation altering degron motif	0.6752
p.K83R	LNCaP-Clone-FGC	prostate	COSMIC	NKENH	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.1944

Kaplan plot for CLEC7A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLEC7A

UniProt ID: Q9BXN2

Entrez ID: 64581

Protein name: C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1) (CD antigen CD369)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLEC7A in