DegronMD

Uniprot ID: Q9BXN2

Source protein: C-type lectin domain family 7 member A

Source gene: CLEC7A

Class: DEG_APCC_KENBOX_2

Location: 88:92

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5203

ASA_SCORE: 116.84

COIL: 0.5848

CONS_SCORE: 0.8914

DSS_SCORE: 0.5358

HELIX: 0.399

FCONS_SCORE: 1.2008

RIG_SCORE: 0.6373

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E90D	TCGA-2Y-A9H5	LIHC	TCGA	NKENH	DEG_APCC_KENBOX_2	0.6758
p.E90D	DO219529	LIHC	ICGC	NKENH	DEG_APCC_KENBOX_2	0.6758
p.L85I	TCGA-B5-A0JY	UCEC	TCGA	NKENH	DEG_APCC_KENBOX_2	0.25
p.L85I	TCGA-EO-A3B0	UCEC	TCGA	NKENH	DEG_APCC_KENBOX_2	0.25
p.L85I	DO219773	UCEC	ICGC	NKENH	DEG_APCC_KENBOX_2	0.25
p.L85I	DO43041	UCEC	ICGC	NKENH	DEG_APCC_KENBOX_2	0.25
p.E84K	DO44045	BLCA	ICGC	NKENH	DEG_APCC_KENBOX_2	0.2222
p.C96G	DO225293	BRCA	ICGC	NKENH	DEG_APCC_KENBOX_2	0.2222
p.C96G	DO227475	BRCA	ICGC	NKENH	DEG_APCC_KENBOX_2	0.2222
p.F91C	DO225395	BRCA	ICGC	NKENH	DEG_APCC_KENBOX_2	0.7108
p.S81R	DO223732	CESC	ICGC	NKENH	DEG_APCC_KENBOX_2	0.1389
p.I98L	DO222762	COCA	ICGC	NKENH	DEG_APCC_KENBOX_2	0.1667
p.S94Y	DO222846	COCA	ICGC	NKENH	DEG_APCC_KENBOX_2	0.2778
p.R87K	DO233168	GACA	ICGC	NKENH	DEG_APCC_KENBOX_2	0.3056
p.S81N	DO22333	LGG	ICGC	NKENH	DEG_APCC_KENBOX_2	0.1389
p.P96T	DO229041	LICA	ICGC	NKENH	DEG_APCC_KENBOX_2	0.2222
p.H92Q	DO229009	LICA	ICGC	NKENH	DEG_APCC_KENBOX_2	0.647
p.I97M	DO45151	LIRI	ICGC	NKENH	DEG_APCC_KENBOX_2	0.1944
p.G86R	DO220899	MELA	ICGC	NKENH	DEG_APCC_KENBOX_2	0.2778
p.G86R	DO229459	SKCA	ICGC	NKENH	DEG_APCC_KENBOX_2	0.2778
p.S94F	DO50287	SKCM	ICGC	NKENH	DEG_APCC_KENBOX_2	0.2778
p.S99Y	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	NKENH	DEG_APCC_KENBOX_2	0.1389
p.S91P	Capan-2	pancreas	COSMIC	NKENH	DEG_APCC_KENBOX_2	0.6752
p.K83R	LNCaP-Clone-FGC	prostate	COSMIC	NKENH	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXN2	C-type lectin domain family 7 member A	DEG_APCC_KENBOX_2	88:92	NKENH	APC,CDC20,FZR1	0.5203	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons