DegronMD - Q9BXP5(SRRT)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A748V	TCGA-77-8146	LUSC	TCGA	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0556
p.A748V	TCGA-D1-A174	UCEC	TCGA	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0556
p.A748V	DO27263	LUSC	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0556
p.A748V	DO40900	UCEC	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0556
p.T755A	TCGA-85-8664	LUSC	TCGA	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.25
p.T755A	DO45469	LUSC	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.25
p.R759L	TCGA-95-7562	LUAD	TCGA	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.8428
p.R759L	DO51196	LUAD	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.8428
p.F749L	TCGA-AJ-A5DW	UCEC	TCGA	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0833
p.F749L	DO50075	UCEC	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0833
p.A774T	TCGA-AP-A1DV	UCEC	TCGA	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.1111
p.A774T	DO43186	UCEC	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.1111
p.I776V	TCGA-B4-5838	KIRC	TCGA	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0556
p.R759H	TCGA-BS-A0TJ	UCEC	TCGA	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.8244
p.R759H	DO42953	UCEC	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.8244
p.R759H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.8244
p.R759H	ACH-001127	Leukemia	CCLE	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.8244
p.R759H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.8244
p.A748T	TCGA-E9-A22H	BRCA	TCGA	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0556
p.A748T	DO4293	BRCA	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0556
p.A748T	DO233932	GACA	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0556
p.S776G	DO20249	KIRC	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0556
p.L776V	DO231690	LINC	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0556
p.Q775E	DO27777	MALY	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0833
p.I776M	SIDM01051	Ovarian Carcinoma	GDSC	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0556
p.I776M	EFO-27	ovary	COSMIC	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0556
p.I775M	EFO-27	ovary	COSMIC	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation rewiring degron network	0.0833
p.R758H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	KRPALPEIK	DEG_APCC_DBOX_1	758:766	Mutation altering degron motif	0.8244

Kaplan plot for SRRT in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SRRT

UniProt ID: Q9BXP5

Entrez ID: 51593

Protein name: Serrate RNA effector molecule homolog (Arsenite-resistance protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SRRT in