DegronMD

Uniprot ID: Q9BXP5

Source protein: Serrate RNA effector molecule homolog

Source gene: SRRT

Class: DEG_APCC_DBOX_1

Location: 758:766

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9939

ASA_SCORE: 99.0444

COIL: 0.9532

CONS_SCORE: 0.4435

DSS_SCORE: 0.5485

HELIX: 0.0274

FCONS_SCORE: 0.9986

RIG_SCORE: 0.72

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A748V	TCGA-77-8146	LUSC	TCGA	KRPALPEIK	DEG_APCC_DBOX_1	0.0556
p.A748V	TCGA-D1-A174	UCEC	TCGA	KRPALPEIK	DEG_APCC_DBOX_1	0.0556
p.A748V	DO27263	LUSC	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	0.0556
p.A748V	DO40900	UCEC	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	0.0556
p.T755A	TCGA-85-8664	LUSC	TCGA	KRPALPEIK	DEG_APCC_DBOX_1	0.25
p.T755A	DO45469	LUSC	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	0.25
p.R759L	TCGA-95-7562	LUAD	TCGA	KRPALPEIK	DEG_APCC_DBOX_1	0.8428
p.R759L	DO51196	LUAD	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	0.8428
p.F749L	TCGA-AJ-A5DW	UCEC	TCGA	KRPALPEIK	DEG_APCC_DBOX_1	0.0833
p.F749L	DO50075	UCEC	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	0.0833
p.A774T	TCGA-AP-A1DV	UCEC	TCGA	KRPALPEIK	DEG_APCC_DBOX_1	0.1111
p.A774T	DO43186	UCEC	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	0.1111
p.I776V	TCGA-B4-5838	KIRC	TCGA	KRPALPEIK	DEG_APCC_DBOX_1	0.0556
p.R759H	TCGA-BS-A0TJ	UCEC	TCGA	KRPALPEIK	DEG_APCC_DBOX_1	0.8244
p.R759H	DO42953	UCEC	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	0.8244
p.R759H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	KRPALPEIK	DEG_APCC_DBOX_1	0.8244
p.R759H	ACH-001127	Leukemia	CCLE	KRPALPEIK	DEG_APCC_DBOX_1	0.8244
p.R759H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	KRPALPEIK	DEG_APCC_DBOX_1	0.8244
p.A748T	TCGA-E9-A22H	BRCA	TCGA	KRPALPEIK	DEG_APCC_DBOX_1	0.0556
p.A748T	DO4293	BRCA	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	0.0556
p.A748T	DO233932	GACA	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	0.0556
p.S776G	DO20249	KIRC	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	0.0556
p.L776V	DO231690	LINC	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	0.0556
p.Q775E	DO27777	MALY	ICGC	KRPALPEIK	DEG_APCC_DBOX_1	0.0833
p.I776M	SIDM01051	Ovarian Carcinoma	GDSC	KRPALPEIK	DEG_APCC_DBOX_1	0.0556
p.I776M	EFO-27	ovary	COSMIC	KRPALPEIK	DEG_APCC_DBOX_1	0.0556
p.I775M	EFO-27	ovary	COSMIC	KRPALPEIK	DEG_APCC_DBOX_1	0.0833
p.R758H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	KRPALPEIK	DEG_APCC_DBOX_1	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRPALPEIK

Degron related mutations and impact score

Drug responses associated with SRRT mutations

All proteins holding degron of KRPALPEIK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXP5	Serrate RNA effector molecule homolog	DEG_APCC_DBOX_1	758:766	KRPALPEIK	APC,CDC20,FZR1	0.9939	More...