DegronMD - Q9BXU7(USP26)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S117N	TCGA-06-5416	GBM	TCGA	VFSST	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.3056
p.S117N	DO10880	GBM	ICGC	VFSST	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.3056
p.K125M	TCGA-61-2095	OV	TCGA	VFSST	DEG_SPOP_SBC_1	118:122	Mutation substituting flanking lysine	0.3611
p.K125M	DO27987	OV	ICGC	VFSST	DEG_SPOP_SBC_1	118:122	Mutation substituting flanking lysine	0.3611
p.G113V	TCGA-95-7562	LUAD	TCGA	VFSST	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.1944
p.G113V	DO51196	LUAD	ICGC	VFSST	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.1944
p.K129T	TCGA-AA-3984	COAD	TCGA	VFSST	DEG_SPOP_SBC_1	118:122	Mutation substituting flanking lysine	0.25
p.K129T	TCGA-EO-A3AV	UCEC	TCGA	VFSST	DEG_SPOP_SBC_1	118:122	Mutation substituting flanking lysine	0.25
p.K129T	DO9002	COAD	ICGC	VFSST	DEG_SPOP_SBC_1	118:122	Mutation substituting flanking lysine	0.25
p.K129T	DO52412	UCEC	ICGC	VFSST	DEG_SPOP_SBC_1	118:122	Mutation substituting flanking lysine	0.25
p.K114N	TCGA-ER-A1A1	SKCM	TCGA	VFSST	DEG_SPOP_SBC_1	118:122	Mutation substituting flanking lysine	0.3333
p.K114N	DO37413	SKCM	ICGC	VFSST	DEG_SPOP_SBC_1	118:122	Mutation substituting flanking lysine	0.3333
p.T122I	TCGA-VQ-A8E3	STAD	TCGA	VFSST	DEG_SPOP_SBC_1	118:122	Mutation altering degron motif	0.7078
p.T122I	DO51759	STAD	ICGC	VFSST	DEG_SPOP_SBC_1	118:122	Mutation altering degron motif	0.7078
p.K129N	DO229052	LICA	ICGC	VFSST	DEG_SPOP_SBC_1	118:122	Mutation substituting flanking lysine	0.25
p.E126K	DO222562	MELA	ICGC	VFSST	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.2222
p.S131L	DO222775	MELA	ICGC	VFSST	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.0833
p.S131L	DO218863	SKCA	ICGC	VFSST	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.0833
p.T130A	ACH-000128	Brain Cancer	CCLE	VFSST	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.1111
p.F132L	ACH-000179	Lung Cancer	CCLE	VFSST	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.0556

Kaplan plot for USP26 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP26

UniProt ID: Q9BXU7

Entrez ID: 83844

Protein name: Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.4.19.12) (Deubiquitinating enzyme 26) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP26 in