DegronMD

Uniprot ID: Q9BXU7

Source protein: Ubiquitin carboxyl-terminal hydrolase 26

Source gene: USP26

Class: DEG_SPOP_SBC_1

Location: 118:122

E3 ligase: SPOP

DEGRON score: 0.9964

ASA_SCORE: 81.26

COIL: 0.8344

CONS_SCORE: 0.3814

DSS_SCORE: 0.6037

HELIX: 0.066

FCONS_SCORE: 1.1553

RIG_SCORE: 0.687

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S117N	TCGA-06-5416	GBM	TCGA	VFSST	DEG_SPOP_SBC_1	0.3056
p.S117N	DO10880	GBM	ICGC	VFSST	DEG_SPOP_SBC_1	0.3056
p.K125M	TCGA-61-2095	OV	TCGA	VFSST	DEG_SPOP_SBC_1	0.3611
p.K125M	DO27987	OV	ICGC	VFSST	DEG_SPOP_SBC_1	0.3611
p.G113V	TCGA-95-7562	LUAD	TCGA	VFSST	DEG_SPOP_SBC_1	0.1944
p.G113V	DO51196	LUAD	ICGC	VFSST	DEG_SPOP_SBC_1	0.1944
p.K129T	TCGA-AA-3984	COAD	TCGA	VFSST	DEG_SPOP_SBC_1	0.25
p.K129T	TCGA-EO-A3AV	UCEC	TCGA	VFSST	DEG_SPOP_SBC_1	0.25
p.K129T	DO9002	COAD	ICGC	VFSST	DEG_SPOP_SBC_1	0.25
p.K129T	DO52412	UCEC	ICGC	VFSST	DEG_SPOP_SBC_1	0.25
p.K114N	TCGA-ER-A1A1	SKCM	TCGA	VFSST	DEG_SPOP_SBC_1	0.3333
p.K114N	DO37413	SKCM	ICGC	VFSST	DEG_SPOP_SBC_1	0.3333
p.T122I	TCGA-VQ-A8E3	STAD	TCGA	VFSST	DEG_SPOP_SBC_1	0.7078
p.T122I	DO51759	STAD	ICGC	VFSST	DEG_SPOP_SBC_1	0.7078
p.K129N	DO229052	LICA	ICGC	VFSST	DEG_SPOP_SBC_1	0.25
p.E126K	DO222562	MELA	ICGC	VFSST	DEG_SPOP_SBC_1	0.2222
p.S131L	DO222775	MELA	ICGC	VFSST	DEG_SPOP_SBC_1	0.0833
p.S131L	DO218863	SKCA	ICGC	VFSST	DEG_SPOP_SBC_1	0.0833
p.T130A	ACH-000128	Brain Cancer	CCLE	VFSST	DEG_SPOP_SBC_1	0.1111
p.F132L	ACH-000179	Lung Cancer	CCLE	VFSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXU7	Ubiquitin carboxyl-terminal hydrolase 26	DEG_SPOP_SBC_1	118:122	VFSST	SPOP	0.9964	More...
Q9Y4C8	Probable RNA-binding protein 19	DEG_SPOP_SBC_1	661:665	VFSST	SPOP	0.9388	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons