DegronMD

Uniprot ID: Q9Y4C8

Source protein: Probable RNA-binding protein 19

Source gene: RBM19

Class: DEG_SPOP_SBC_1

Location: 661:665

E3 ligase: SPOP

DEGRON score: 0.9388

ASA_SCORE: 65.3

COIL: 0.712

CONS_SCORE: 0.3043

DSS_SCORE: 0.2939

HELIX: 0.0588

FCONS_SCORE: 0.6702

RIG_SCORE: 0.7254

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G660S	TCGA-05-4410	LUAD	TCGA	VFSST	DEG_SPOP_SBC_1	0.3056
p.G660S	DO25426	LUAD	ICGC	VFSST	DEG_SPOP_SBC_1	0.3056
p.V661I	TCGA-24-2260	OV	TCGA	VFSST	DEG_SPOP_SBC_1	0.7076
p.V661I	TCGA-B5-A3FC	UCEC	TCGA	VFSST	DEG_SPOP_SBC_1	0.7076
p.V661I	DO29950	OV	ICGC	VFSST	DEG_SPOP_SBC_1	0.7076
p.V661I	DO41871	UCEC	ICGC	VFSST	DEG_SPOP_SBC_1	0.7076
p.S664I	TCGA-44-6777	LUAD	TCGA	VFSST	DEG_SPOP_SBC_1	0.7341
p.S664I	DO23645	LUAD	ICGC	VFSST	DEG_SPOP_SBC_1	0.7341
p.G660V	TCGA-60-2714	LUSC	TCGA	VFSST	DEG_SPOP_SBC_1	0.3056
p.G660V	DO26530	LUSC	ICGC	VFSST	DEG_SPOP_SBC_1	0.3056
p.W656L	TCGA-D3-A2JC	SKCM	TCGA	VFSST	DEG_SPOP_SBC_1	0.1944
p.W656L	DO47578	SKCM	ICGC	VFSST	DEG_SPOP_SBC_1	0.1944
p.K671N	TCGA-VQ-A8P2	STAD	TCGA	VFSST	DEG_SPOP_SBC_1	0.2778
p.K671N	DO51761	STAD	ICGC	VFSST	DEG_SPOP_SBC_1	0.2778
p.L654V	TCGA-ZF-AA4X	BLCA	TCGA	VFSST	DEG_SPOP_SBC_1	0.1389
p.L654V	DO219091	BLCA	ICGC	VFSST	DEG_SPOP_SBC_1	0.1389
p.T665A	DO229013	COCA	ICGC	VFSST	DEG_SPOP_SBC_1	0.7139
p.T665A	DO229003	COCA	ICGC	VFSST	DEG_SPOP_SBC_1	0.7139
p.T665A	DO229005	COCA	ICGC	VFSST	DEG_SPOP_SBC_1	0.7139
p.T665A	DO228941	LICA	ICGC	VFSST	DEG_SPOP_SBC_1	0.7139
p.T665A	DO229047	LICA	ICGC	VFSST	DEG_SPOP_SBC_1	0.7139
p.T665A	DO221050	WT	ICGC	VFSST	DEG_SPOP_SBC_1	0.7139
p.D674E	DO228948	LICA	ICGC	VFSST	DEG_SPOP_SBC_1	0.0833
p.D674E	DO229037	LICA	ICGC	VFSST	DEG_SPOP_SBC_1	0.0833
p.T675I	SIDM02074	Esophageal Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.5
p.T665S	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00773	Non-Cancerous	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00845	Burkitt's Lymphoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00967	Ovarian Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM01126	Small Cell Lung Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00656	Burkitt's Lymphoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00087	Plasma Cell Myeloma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00633	Breast Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00581	Glioblastoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00690	Head and Neck Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00210	Ovarian Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00529	Breast Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00694	Other Solid Cancers	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00265	Ewing's Sarcoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00779	Colorectal Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00493	Other Solid Cancers	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00875	Breast Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM01147	Gastric Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00807	Bladder Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00793	Burkitt's Lymphoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM01133	Other Solid Cancers	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00930	Osteosarcoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00954	Breast Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00431	T-Lymphoblastic Leukemia	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00863	Burkitt's Lymphoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00721	Small Cell Lung Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00774	Breast Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00720	Mesothelioma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00760	Small Cell Lung Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM01173	Rhabdomyosarcoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM01318	Hepatocellular Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM00641	Burkitt's Lymphoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM01409	Bladder Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	EB-3	haematopoietic_and_lymphoid_tissue	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	HCC-15	lung	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	NCI-H64	lung	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	NCI-H716	large_intestine	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	EMC-BAC-1	lung	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	A2780	ovary	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	CAL-72	bone	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	MDA-MB-175-VII	breast	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	NCI-H835	lung	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	NCI-N87	stomach	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	MDA-MB-157	breast	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	NCI-H1963	lung	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	201T	lung	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	HCE-4	oesophagus	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	HUTU-80	small_intestine	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	NCI-H292	lung	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	COLO-680N	oesophagus	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	HCC1806	breast	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	COLO-824	breast	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	H513	pleura	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	TE-441-T	soft_tissue	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	5637	urinary_tract	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.T665S	NCI-H28	pleura	COSMIC	VFSST	DEG_SPOP_SBC_1	0.6005
p.G660D	SIDM00516	Melanoma	GDSC	VFSST	DEG_SPOP_SBC_1	0.3056
p.G660D	ACH-002166	Skin Cancer	CCLE	VFSST	DEG_SPOP_SBC_1	0.3056
p.G660D	MZ7-mel	skin	COSMIC	VFSST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXU7	Ubiquitin carboxyl-terminal hydrolase 26	DEG_SPOP_SBC_1	118:122	VFSST	SPOP	0.9964	More...
Q9Y4C8	Probable RNA-binding protein 19	DEG_SPOP_SBC_1	661:665	VFSST	SPOP	0.9388	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VFSST

Degron related mutations and impact score

Drug responses associated with RBM19 mutations

All proteins holding degron of VFSST