DegronMD - Q9BY44(EIF2A)

EIF2A

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R520Q	TCGA-AJ-A3EL	UCEC	TCGA	PQSTPRNT	DEG_SCF_FBW7_1	515:522	Mutation altering degron motif	0.6218
p.R520Q	TCGA-AZ-4315	COAD	TCGA	PQSTPRNT	DEG_SCF_FBW7_1	515:522	Mutation altering degron motif	0.6218
p.D530Y	TCGA-CA-6717	COAD	TCGA	PQSTPRNT	DEG_SCF_FBW7_1	515:522	Mutation rewiring degron network	0.1111
p.G532R	DO2688	BRCA	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	515:522	Mutation rewiring degron network	0.0556
p.A529T	DO222946	BTCA	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	515:522	Mutation rewiring degron network	0.1389
p.R515Q	DO8842	COAD	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	515:522	Mutation altering degron motif	0.7329
p.R515Q	DO41542	UCEC	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	515:522	Mutation altering degron motif	0.7329
p.D525Y	DO8264	COAD	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	515:522	Mutation rewiring degron network	0.25
p.S517N	DO233766	GACA	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	515:522	Mutation altering degron motif	0.7069
p.Q516R	DO44786	LICA	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	515:522	Mutation altering degron motif	0.6218
p.K518I	DO26425	LUSC	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	515:522	Mutation altering degron motif	0.7531
p.P506S	DO27943	ORCA	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	515:522	Mutation blocking phosphorylation signal	0.5278
p.K513N	DO41903	UCEC	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	515:522	Mutation rewiring degron network	0.2778
p.E527K	ACH-000337	Lung Cancer	CCLE	PQSTPRNT	DEG_SCF_FBW7_1	515:522	Mutation rewiring degron network	0.1944
p.E527K	NCI-H3122	lung	COSMIC	PQSTPRNT	DEG_SCF_FBW7_1	515:522	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc