DegronMD

Uniprot ID: Q9BY44

Source protein: Eukaryotic translation initiation factor 2A

Source gene: EIF2A

Class: DEG_SCF_FBW7_1

Location: 515:522

E3 ligase: FBXW7

DEGRON score: 0.9543

ASA_SCORE: 96.7

COIL: 0.9128

CONS_SCORE: 0.2263

DSS_SCORE: 0.7834

HELIX: 0.0353

FCONS_SCORE: 0.9833

RIG_SCORE: 0.5726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R520Q	TCGA-AJ-A3EL	UCEC	TCGA	PQSTPRNT	DEG_SCF_FBW7_1	0.6218
p.R520Q	TCGA-AZ-4315	COAD	TCGA	PQSTPRNT	DEG_SCF_FBW7_1	0.6218
p.D530Y	TCGA-CA-6717	COAD	TCGA	PQSTPRNT	DEG_SCF_FBW7_1	0.1111
p.G532R	DO2688	BRCA	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	0.0556
p.A529T	DO222946	BTCA	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	0.1389
p.R515Q	DO8842	COAD	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	0.7329
p.R515Q	DO41542	UCEC	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	0.7329
p.D525Y	DO8264	COAD	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	0.25
p.S517N	DO233766	GACA	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	0.7069
p.Q516R	DO44786	LICA	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	0.6218
p.K518I	DO26425	LUSC	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	0.7531
p.P506S	DO27943	ORCA	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	0.5278
p.K513N	DO41903	UCEC	ICGC	PQSTPRNT	DEG_SCF_FBW7_1	0.2778
p.E527K	ACH-000337	Lung Cancer	CCLE	PQSTPRNT	DEG_SCF_FBW7_1	0.1944
p.E527K	NCI-H3122	lung	COSMIC	PQSTPRNT	DEG_SCF_FBW7_1	0.1944

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00959	LAML\|acute_myeloid_leukaemia	p.H491R (No)	GDSC	Salubrinal	13.496
SIDM00660	COREAD\|large_intestine	p.Q499R (No)	GDSC	Salubrinal	31.5066
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.E463* (No)	GDSC	Salubrinal	30.3679
SIDM01111	UNCLASSIFIED\|ewings_sarcoma	p.E571A (No)	GDSC	Salubrinal	30.9726
SIDM00594	LAML\|acute_myeloid_leukaemia	p.H491R (No)	GDSC	Salubrinal	9.734

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BY44	Eukaryotic translation initiation factor 2A	DEG_SCF_FBW7_1	515:522	PQSTPRNT	FBXW7	0.9543	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons