DegronMD - Q9BY76(ANGPTL4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N177H	TCGA-13-1481	OV	TCGA	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation rewiring degron network	0.1111
p.N177H	DO31789	OV	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation rewiring degron network	0.1111
p.P174R	TCGA-58-A46J	LUSC	TCGA	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation rewiring degron network	0.1944
p.P174R	DO45532	LUSC	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation rewiring degron network	0.1944
p.P174Q	TCGA-D3-A1Q3	SKCM	TCGA	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation rewiring degron network	0.1944
p.P174Q	DO47509	SKCM	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation rewiring degron network	0.1944
p.R161Q	TCGA-DF-A2KU	UCEC	TCGA	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation altering degron motif	0.6218
p.R161Q	DO223286	UCEC	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation altering degron motif	0.6218
p.R161Q	SIDM01943	Colorectal Carcinoma	GDSC	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation altering degron motif	0.6218
p.D173N	TCGA-DK-A2I6	BLCA	TCGA	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation rewiring degron network	0.2222
p.D173N	DO798	BLCA	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation rewiring degron network	0.2222
p.D173E	TCGA-DK-A2I6	BLCA	TCGA	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation rewiring degron network	0.2222
p.D173E	DO798	BLCA	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation rewiring degron network	0.2222
p.Q170L	TCGA-EE-A29L	SKCM	TCGA	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation rewiring degron network	0.3056
p.Q170L	DO222599	MELA	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation rewiring degron network	0.3056
p.Q170L	DO37835	SKCM	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation rewiring degron network	0.3056
p.P171S	TCGA-L5-A8NM	ESCA	TCGA	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation rewiring degron network	0.2778
p.V178F	DO228971	LICA	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation rewiring degron network	0.0833
p.D173H	DO49105	PACA	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation rewiring degron network	0.2222
p.P174L	SIDM00216	Colorectal Carcinoma	GDSC	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation rewiring degron network	0.1944
p.P174L	SNU-175	large intestine	COSMIC	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation rewiring degron network	0.1944
p.E167K	SIDM00506	Small Cell Lung Carcinoma	GDSC	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation altering degron motif	0.591
p.P166A	ACH-000971	Colon/Colorectal Cancer	CCLE	RRKRLPEMA	DEG_APCC_DBOX_1	161:169	Mutation altering degron motif	0.6392

Kaplan plot for ANGPTL4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANGPTL4

UniProt ID: Q9BY76

Entrez ID: 51129

Protein name: Angiopoietin-related protein 4 (Angiopoietin-like protein 4) (Hepatic fibrinogen/angiopoietin-related protein) (HFARP) [Cleaved into: ANGPTL4 N-terminal chain; ANGPTL4 C-terminal chain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANGPTL4 in