DegronMD

Uniprot ID: Q9BY76

Source protein: Angiopoietin-related protein 4

Source gene: ANGPTL4

Class: DEG_APCC_DBOX_1

Location: 161:169

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9636

ASA_SCORE: 109.9111

COIL: 0.4772

CONS_SCORE: 0.2871

DSS_SCORE: 0.6502

HELIX: 0.509

FCONS_SCORE: 1.0625

RIG_SCORE: 0.6674

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N177H	TCGA-13-1481	OV	TCGA	RRKRLPEMA	DEG_APCC_DBOX_1	0.1111
p.N177H	DO31789	OV	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	0.1111
p.P174R	TCGA-58-A46J	LUSC	TCGA	RRKRLPEMA	DEG_APCC_DBOX_1	0.1944
p.P174R	DO45532	LUSC	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	0.1944
p.P174Q	TCGA-D3-A1Q3	SKCM	TCGA	RRKRLPEMA	DEG_APCC_DBOX_1	0.1944
p.P174Q	DO47509	SKCM	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	0.1944
p.R161Q	TCGA-DF-A2KU	UCEC	TCGA	RRKRLPEMA	DEG_APCC_DBOX_1	0.6218
p.R161Q	DO223286	UCEC	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	0.6218
p.R161Q	SIDM01943	Colorectal Carcinoma	GDSC	RRKRLPEMA	DEG_APCC_DBOX_1	0.6218
p.D173N	TCGA-DK-A2I6	BLCA	TCGA	RRKRLPEMA	DEG_APCC_DBOX_1	0.2222
p.D173N	DO798	BLCA	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	0.2222
p.D173E	TCGA-DK-A2I6	BLCA	TCGA	RRKRLPEMA	DEG_APCC_DBOX_1	0.2222
p.D173E	DO798	BLCA	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	0.2222
p.Q170L	TCGA-EE-A29L	SKCM	TCGA	RRKRLPEMA	DEG_APCC_DBOX_1	0.3056
p.Q170L	DO222599	MELA	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	0.3056
p.Q170L	DO37835	SKCM	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	0.3056
p.P171S	TCGA-L5-A8NM	ESCA	TCGA	RRKRLPEMA	DEG_APCC_DBOX_1	0.2778
p.V178F	DO228971	LICA	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	0.0833
p.D173H	DO49105	PACA	ICGC	RRKRLPEMA	DEG_APCC_DBOX_1	0.2222
p.P174L	SIDM00216	Colorectal Carcinoma	GDSC	RRKRLPEMA	DEG_APCC_DBOX_1	0.1944
p.P174L	SNU-175	large_intestine	COSMIC	RRKRLPEMA	DEG_APCC_DBOX_1	0.1944
p.E167K	SIDM00506	Small Cell Lung Carcinoma	GDSC	RRKRLPEMA	DEG_APCC_DBOX_1	0.591
p.P166A	ACH-000971	Colon/Colorectal Cancer	CCLE	RRKRLPEMA	DEG_APCC_DBOX_1	0.6392

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BY76	Angiopoietin-related protein 4	DEG_APCC_DBOX_1	161:169	RRKRLPEMA	APC,CDC20,FZR1	0.9636	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons