DegronMD - Q9BY77(POLDIP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R379C	TCGA-4Z-AA80	BLCA	TCGA	NPPAEVDPD	DEG_SIAH_1	388:396	Mutation rewiring degron network	0.0833
p.R379C	DO218986	BLCA	ICGC	NPPAEVDPD	DEG_SIAH_1	388:396	Mutation rewiring degron network	0.0833
p.R380K	TCGA-EE-A2A2	SKCM	TCGA	NPPAEVDPD	DEG_SIAH_1	388:396	Mutation rewiring degron network	0.1111
p.R380K	DO37583	SKCM	ICGC	NPPAEVDPD	DEG_SIAH_1	388:396	Mutation rewiring degron network	0.1111
p.T397I	TCGA-FW-A3R5	SKCM	TCGA	NPPAEVDPD	DEG_SIAH_1	388:396	Mutation rewiring degron network	0.3056
p.T397I	DO37406	SKCM	ICGC	NPPAEVDPD	DEG_SIAH_1	388:396	Mutation rewiring degron network	0.3056
p.P390S	DO222880	MELA	ICGC	NPPAEVDPD	DEG_SIAH_1	388:396	Mutation altering degron motif	0.5641
p.S405C	DO229257	THCA	ICGC	NPPAEVDPD	DEG_SIAH_1	388:396	Mutation blocking phosphorylation signal	0.5278
p.A401S	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	NPPAEVDPD	DEG_SIAH_1	388:396	Mutation rewiring degron network	0.1944
p.A401S	NCI-H1573	lung	COSMIC	NPPAEVDPD	DEG_SIAH_1	388:396	Mutation rewiring degron network	0.1944
p.S385C	SIDM00628	Breast Carcinoma	GDSC	NPPAEVDPD	DEG_SIAH_1	388:396	Mutation blocking phosphorylation signal	0.6944
p.S405F	ACH-000106	Lymphoma	CCLE	NPPAEVDPD	DEG_SIAH_1	388:396	Mutation blocking phosphorylation signal	0.5278
p.S405F	JVM-2	haematopoietic and lymphoid tissue	COSMIC	NPPAEVDPD	DEG_SIAH_1	388:396	Mutation blocking phosphorylation signal	0.5278
p.A384S	ACH-000916	Lung Cancer	CCLE	NPPAEVDPD	DEG_SIAH_1	388:396	Mutation rewiring degron network	0.2222
p.A384S	NCI-H1573	lung	COSMIC	NPPAEVDPD	DEG_SIAH_1	388:396	Mutation rewiring degron network	0.2222
p.P385L	SK-MEL-5	skin	COSMIC	NPPAEVDPD	DEG_SIAH_1	388:396	Mutation blocking phosphorylation signal	0.6944
p.T383M	SNU-1040	large intestine	COSMIC	NPPAEVDPD	DEG_SIAH_1	388:396	Mutation blocking phosphorylation signal	0.6389

Kaplan plot for POLDIP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POLDIP3

UniProt ID: Q9BY77

Entrez ID: 84271

Protein name: Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POLDIP3 in