DegronMD

Uniprot ID: Q9BY77

Source protein: Polymerase delta-interacting protein 3

Source gene: POLDIP3

Class: DEG_SIAH_1

Location: 388:396

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9988

ASA_SCORE: 82.4778

COIL: 0.7636

CONS_SCORE: 0.3801

DSS_SCORE: 0.5482

HELIX: 0.2074

FCONS_SCORE: 1.216

RIG_SCORE: 0.6472

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R379C	TCGA-4Z-AA80	BLCA	TCGA	NPPAEVDPD	DEG_SIAH_1	0.0833
p.R379C	DO218986	BLCA	ICGC	NPPAEVDPD	DEG_SIAH_1	0.0833
p.R380K	TCGA-EE-A2A2	SKCM	TCGA	NPPAEVDPD	DEG_SIAH_1	0.1111
p.R380K	DO37583	SKCM	ICGC	NPPAEVDPD	DEG_SIAH_1	0.1111
p.T397I	TCGA-FW-A3R5	SKCM	TCGA	NPPAEVDPD	DEG_SIAH_1	0.3056
p.T397I	DO37406	SKCM	ICGC	NPPAEVDPD	DEG_SIAH_1	0.3056
p.P390S	DO222880	MELA	ICGC	NPPAEVDPD	DEG_SIAH_1	0.5641
p.S405C	DO229257	THCA	ICGC	NPPAEVDPD	DEG_SIAH_1	0.5278
p.A401S	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	NPPAEVDPD	DEG_SIAH_1	0.1944
p.A401S	NCI-H1573	lung	COSMIC	NPPAEVDPD	DEG_SIAH_1	0.1944
p.S385C	SIDM00628	Breast Carcinoma	GDSC	NPPAEVDPD	DEG_SIAH_1	0.6944
p.S405F	ACH-000106	Lymphoma	CCLE	NPPAEVDPD	DEG_SIAH_1	0.5278
p.S405F	JVM-2	haematopoietic_and_lymphoid_tissue	COSMIC	NPPAEVDPD	DEG_SIAH_1	0.5278
p.A384S	ACH-000916	Lung Cancer	CCLE	NPPAEVDPD	DEG_SIAH_1	0.2222
p.A384S	NCI-H1573	lung	COSMIC	NPPAEVDPD	DEG_SIAH_1	0.2222
p.P385L	SK-MEL-5	skin	COSMIC	NPPAEVDPD	DEG_SIAH_1	0.6944
p.T383M	SNU-1040	large_intestine	COSMIC	NPPAEVDPD	DEG_SIAH_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BY77	Polymerase delta-interacting protein 3	DEG_SIAH_1	388:396	NPPAEVDPD	SIAH1,SIAH2,SIAH3	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons