CDHR2
UniProt ID: Q9BYE9
Entrez ID: 54825
Protein name: Cadherin-related family member 2 (Protocadherin LKC) (PC-LKC) (Protocadherin-24)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with mi...
FUNCTION: Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409). May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771). {ECO:0000269|PubMed:12117771, ECO:0000269|PubMed:24725409}.
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GO - Biological processes (BP):
cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell differentiation [GO:0030855]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intermicrovillar adhesion [GO:0090675]; negative regulation of cell growth involved in co...
cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell differentiation [GO:0030855]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intermicrovillar adhesion [GO:0090675]; negative regulation of cell growth involved in contact inhibition [GO:0060243]; regulation of microvillus length [GO:0032532]
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GO - Molecular function (MF):
calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]...
calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]
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GO - Cellular component (CC):
apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; cell junction [GO:0030054]; extracellular exosome [GO:0070062]; microvillus membrane [GO:0031528]; spanning component of plasma membrane [GO:0044214]...
apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; cell junction [GO:0030054]; extracellular exosome [GO:0070062]; microvillus membrane [GO:0031528]; spanning component of plasma membrane [GO:0044214]
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CDHR2
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*NOTE: the Kaplan plots were collected from OncoLnc