DegronMD

Uniprot ID: Q9BYE9

Source protein: Cadherin-related family member 2

Source gene: CDHR2

Class: LIG_APCC_ABBA_1

Location: 1028:1033

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9141

ASA_SCORE: 67.5833

COIL: 0.678

CONS_SCORE: 0.4843

DSS_SCORE: 0.3693

HELIX: 0.0188

FCONS_SCORE: 0.8011

RIG_SCORE: 0.7693

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1022V	TCGA-AA-3663	COAD	TCGA	LGPFLE	LIG_APCC_ABBA_1	0.1667
p.A1022V	DO9346	COAD	ICGC	LGPFLE	LIG_APCC_ABBA_1	0.1667
p.G1029D	TCGA-AP-A1DK	UCEC	TCGA	LGPFLE	LIG_APCC_ABBA_1	0.6087
p.G1029D	DO42033	UCEC	ICGC	LGPFLE	LIG_APCC_ABBA_1	0.6087
p.S1027F	TCGA-D3-A3C8	SKCM	TCGA	LGPFLE	LIG_APCC_ABBA_1	0.3056
p.S1027F	TCGA-FS-A1ZN	SKCM	TCGA	LGPFLE	LIG_APCC_ABBA_1	0.3056
p.S1027F	DO47636	SKCM	ICGC	LGPFLE	LIG_APCC_ABBA_1	0.3056
p.S1027F	DO38165	SKCM	ICGC	LGPFLE	LIG_APCC_ABBA_1	0.3056
p.L1038M	TCGA-DA-A1I5	SKCM	TCGA	LGPFLE	LIG_APCC_ABBA_1	0.1944
p.L1038M	DO37447	SKCM	ICGC	LGPFLE	LIG_APCC_ABBA_1	0.1944
p.T1035N	TCGA-EJ-7317	PRAD	TCGA	LGPFLE	LIG_APCC_ABBA_1	0.2778
p.T1035N	DO36365	PRAD	ICGC	LGPFLE	LIG_APCC_ABBA_1	0.2778
p.V1043M	DO227709	COCA	ICGC	LGPFLE	LIG_APCC_ABBA_1	0.0556
p.D1024N	DO222749	MELA	ICGC	LGPFLE	LIG_APCC_ABBA_1	0.2222
p.P1030S	SIDM01619	Endometrial Carcinoma	GDSC	LGPFLE	LIG_APCC_ABBA_1	0.6752
p.P1030S	ACH-000984	Endometrial/Uterine Cancer	CCLE	LGPFLE	LIG_APCC_ABBA_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYE9	Cadherin-related family member 2	LIG_APCC_ABBA_1	1028:1033	LGPFLE	APC,CDC20,FZR1	0.9141	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons