DegronMD - Q9BYL1(SAMD10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E49K	TCGA-AO-A03M	BRCA	TCGA	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1667
p.E49K	TCGA-CV-6936	HNSC	TCGA	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1667
p.E49K	TCGA-EK-A2RA	CESC	TCGA	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1667
p.E49K	DO2216	BRCA	ICGC	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1667
p.E49K	DO51601	CESC	ICGC	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1667
p.E49K	DO14210	HNSC	ICGC	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1667
p.W65S	TCGA-DK-A3IL	BLCA	TCGA	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.25
p.W65S	DO555	BLCA	ICGC	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.25
p.P52L	TCGA-VQ-A94U	STAD	TCGA	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.25
p.P52L	DO222378	STAD	ICGC	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.25
p.T64K	DO228976	LICA	ICGC	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.2778
p.S70R	DO229019	LICA	ICGC	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1111
p.A48D	DO229029	LICA	ICGC	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1389
p.S47L	DO231645	LINC	ICGC	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation blocking phosphorylation signal	0.5556
p.A48S	DO229259	THCA	ICGC	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1389
p.R69L	DO229211	THCA	ICGC	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1389
p.R57Q	DO231493	THCA	ICGC	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6218
p.R69C	SIDM00773	Non-Cancerous	GDSC	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1389
p.R69C	SIDM00774	Breast Carcinoma	GDSC	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1389
p.R69C	ACH-000691	Breast Cancer	CCLE	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1389
p.R69C	ACH-002381	Non-Cancerous	CCLE	LPRTPGTS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1389

Kaplan plot for SAMD10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SAMD10

UniProt ID: Q9BYL1

Entrez ID: 140700

Protein name: Sterile alpha motif domain-containing protein 10 (SAM domain-containing protein 10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SAMD10 in