DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LPRTPGTS
Uniprot ID:
Q9BYL1
Source protein:
Sterile alpha motif domain-containing protein 10
Source gene:
SAMD10
Class:
DEG_SCF_FBW7_1
Location:
55:62
E3 ligase:
FBXW7
DEGRON score:
0.9909
ASA_SCORE:
76.9125
COIL:
0.9181
CONS_SCORE:
0.5113
DSS_SCORE:
0.4775
HELIX:
0.039
FCONS_SCORE:
1.0655
RIG_SCORE:
0.6597
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E49K
TCGA-AO-A03M
BRCA
TCGA
LPRTPGTS
DEG_SCF_FBW7_1
0.1667
p.E49K
TCGA-CV-6936
HNSC
TCGA
LPRTPGTS
DEG_SCF_FBW7_1
0.1667
p.E49K
TCGA-EK-A2RA
CESC
TCGA
LPRTPGTS
DEG_SCF_FBW7_1
0.1667
p.E49K
DO2216
BRCA
ICGC
LPRTPGTS
DEG_SCF_FBW7_1
0.1667
p.E49K
DO51601
CESC
ICGC
LPRTPGTS
DEG_SCF_FBW7_1
0.1667
p.E49K
DO14210
HNSC
ICGC
LPRTPGTS
DEG_SCF_FBW7_1
0.1667
p.W65S
TCGA-DK-A3IL
BLCA
TCGA
LPRTPGTS
DEG_SCF_FBW7_1
0.25
p.W65S
DO555
BLCA
ICGC
LPRTPGTS
DEG_SCF_FBW7_1
0.25
p.P52L
TCGA-VQ-A94U
STAD
TCGA
LPRTPGTS
DEG_SCF_FBW7_1
0.25
p.P52L
DO222378
STAD
ICGC
LPRTPGTS
DEG_SCF_FBW7_1
0.25
p.T64K
DO228976
LICA
ICGC
LPRTPGTS
DEG_SCF_FBW7_1
0.2778
p.S70R
DO229019
LICA
ICGC
LPRTPGTS
DEG_SCF_FBW7_1
0.1111
p.A48D
DO229029
LICA
ICGC
LPRTPGTS
DEG_SCF_FBW7_1
0.1389
p.S47L
DO231645
LINC
ICGC
LPRTPGTS
DEG_SCF_FBW7_1
0.5556
p.A48S
DO229259
THCA
ICGC
LPRTPGTS
DEG_SCF_FBW7_1
0.1389
p.R69L
DO229211
THCA
ICGC
LPRTPGTS
DEG_SCF_FBW7_1
0.1389
p.R57Q
DO231493
THCA
ICGC
LPRTPGTS
DEG_SCF_FBW7_1
0.6218
p.R69C
SIDM00773
Non-Cancerous
GDSC
LPRTPGTS
DEG_SCF_FBW7_1
0.1389
p.R69C
SIDM00774
Breast Carcinoma
GDSC
LPRTPGTS
DEG_SCF_FBW7_1
0.1389
p.R69C
ACH-000691
Breast Cancer
CCLE
LPRTPGTS
DEG_SCF_FBW7_1
0.1389
p.R69C
ACH-002381
Non-Cancerous
CCLE
LPRTPGTS
DEG_SCF_FBW7_1
0.1389
Drug responses associated with SAMD10 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPRTPGTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BYL1
Sterile alpha motif domain-containing protein 10
DEG_SCF_FBW7_1
55:62
LPRTPGTS
FBXW7
0.9909
More...