DegronMD - Q9BYV6(TRIM55)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P458L	TCGA-95-7562	LUAD	TCGA	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation altering degron motif	0.6471
p.P458L	DO51196	LUAD	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation altering degron motif	0.6471
p.P461T	TCGA-AA-3864	COAD	TCGA	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation altering degron motif	0.7031
p.P461T	DO8490	COAD	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation altering degron motif	0.7031
p.R451Q	TCGA-AA-3875	COAD	TCGA	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation rewiring degron network	0.1667
p.R451Q	DO222830	BTCA	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation rewiring degron network	0.1667
p.R451Q	DO9282	COAD	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation rewiring degron network	0.1667
p.G467R	TCGA-BF-A1PX	SKCM	TCGA	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation rewiring degron network	0.25
p.G467R	DO51236	SKCM	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation rewiring degron network	0.25
p.S463G	TCGA-BS-A0UF	UCEC	TCGA	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation altering degron motif	0.5882
p.S463G	DO41488	UCEC	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation altering degron motif	0.5882
p.G448S	TCGA-EE-A3AC	SKCM	TCGA	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation rewiring degron network	0.0833
p.G448S	DO37631	SKCM	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation rewiring degron network	0.0833
p.G448D	TCGA-ER-A2NG	SKCM	TCGA	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation rewiring degron network	0.0833
p.G448D	DO47552	SKCM	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation rewiring degron network	0.0833
p.G465C	TCGA-FW-A3R5	SKCM	TCGA	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation rewiring degron network	0.3056
p.G465C	DO37406	SKCM	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation rewiring degron network	0.3056
p.E464K	DO228483	BRCA	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation altering degron motif	0.7022
p.R451W	DO227657	COCA	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation rewiring degron network	0.1667
p.S463N	DO234370	ESAD	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation altering degron motif	0.5958
p.P461Q	DO223145	ESCA	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation altering degron motif	0.7035
p.Q468L	SIDM00312	Plasma Cell Myeloma	GDSC	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation rewiring degron network	0.2222
p.Q468L	ACH-000183	Myeloma	CCLE	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation rewiring degron network	0.2222
p.Q468L	L-363	haematopoietic and lymphoid tissue	COSMIC	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation rewiring degron network	0.2222
p.S449Y	L-1236	haematopoietic and lymphoid tissue	COSMIC	PPCTPGSE	DEG_SCF_FBW7_2	457:464	Mutation rewiring degron network	0.1111

Kaplan plot for TRIM55 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIM55

UniProt ID: Q9BYV6

Entrez ID: 84675

Protein name: Tripartite motif-containing protein 55 (Muscle-specific RING finger protein 2) (MuRF-2) (MuRF2) (RING finger protein 29)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIM55 in