DegronMD

Uniprot ID: Q9BYV6

Source protein: Tripartite motif-containing protein 55

Source gene: TRIM55

Class: DEG_SCF_FBW7_2

Location: 457:464

E3 ligase: FBXW7

DEGRON score: 0.9146

ASA_SCORE: 82.8

COIL: 0.923

CONS_SCORE: 0.2928

DSS_SCORE: 0.6781

HELIX: 0.0294

FCONS_SCORE: 0.9075

RIG_SCORE: 0.6412

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P458L	TCGA-95-7562	LUAD	TCGA	PPCTPGSE	DEG_SCF_FBW7_2	0.6471
p.P458L	DO51196	LUAD	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	0.6471
p.P461T	TCGA-AA-3864	COAD	TCGA	PPCTPGSE	DEG_SCF_FBW7_2	0.7031
p.P461T	DO8490	COAD	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	0.7031
p.R451Q	TCGA-AA-3875	COAD	TCGA	PPCTPGSE	DEG_SCF_FBW7_2	0.1667
p.R451Q	DO222830	BTCA	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	0.1667
p.R451Q	DO9282	COAD	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	0.1667
p.G467R	TCGA-BF-A1PX	SKCM	TCGA	PPCTPGSE	DEG_SCF_FBW7_2	0.25
p.G467R	DO51236	SKCM	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	0.25
p.S463G	TCGA-BS-A0UF	UCEC	TCGA	PPCTPGSE	DEG_SCF_FBW7_2	0.5882
p.S463G	DO41488	UCEC	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	0.5882
p.G448S	TCGA-EE-A3AC	SKCM	TCGA	PPCTPGSE	DEG_SCF_FBW7_2	0.0833
p.G448S	DO37631	SKCM	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	0.0833
p.G448D	TCGA-ER-A2NG	SKCM	TCGA	PPCTPGSE	DEG_SCF_FBW7_2	0.0833
p.G448D	DO47552	SKCM	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	0.0833
p.G465C	TCGA-FW-A3R5	SKCM	TCGA	PPCTPGSE	DEG_SCF_FBW7_2	0.3056
p.G465C	DO37406	SKCM	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	0.3056
p.E464K	DO228483	BRCA	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	0.7022
p.R451W	DO227657	COCA	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	0.1667
p.S463N	DO234370	ESAD	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	0.5958
p.P461Q	DO223145	ESCA	ICGC	PPCTPGSE	DEG_SCF_FBW7_2	0.7035
p.Q468L	SIDM00312	Plasma Cell Myeloma	GDSC	PPCTPGSE	DEG_SCF_FBW7_2	0.2222
p.Q468L	ACH-000183	Myeloma	CCLE	PPCTPGSE	DEG_SCF_FBW7_2	0.2222
p.Q468L	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	PPCTPGSE	DEG_SCF_FBW7_2	0.2222
p.S449Y	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	PPCTPGSE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYV6	Tripartite motif-containing protein 55	DEG_SCF_FBW7_2	457:464	PPCTPGSE	FBXW7	0.9146	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons