DegronMD - Q9BZF9(UACA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S429Y	TCGA-AP-A0LM	UCEC	TCGA	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.2778
p.T434M	TCGA-AX-A3FT	UCEC	TCGA	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.1389
p.T434M	SIDM01233	Colorectal Carcinoma	GDSC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.1389
p.T434M	C2BBe1	large intestine	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.1389
p.S435P	TCGA-BR-4361	STAD	TCGA	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.1111
p.R424I	TCGA-EO-A22R	UCEC	TCGA	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation altering degron motif	0.6991
p.R437Q	DO9114	COAD	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation blocking phosphorylation signal	0.5
p.R437Q	DO43306	UCEC	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation blocking phosphorylation signal	0.5
p.R437Q	DO223286	UCEC	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation blocking phosphorylation signal	0.5
p.R437Q	HCC2998	large intestine	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation blocking phosphorylation signal	0.5
p.K430N	DO222762	COCA	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.25
p.K430N	DO49060	HNSC	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.25
p.L410V	DO228696	EOPC	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.0833
p.S422P	DO38887	STAD	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation altering degron motif	0.6752
p.T421M	DO40801	UCEC	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation altering degron motif	0.7423
p.T421M	C2BBe1	large intestine	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation altering degron motif	0.7423
p.S416Y	DO43306	UCEC	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.25
p.R411I	DO42713	UCEC	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.1111
p.R435Q	HCC2998	large intestine	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.1111
p.E421K	TASK1	bone	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation altering degron motif	0.7022
p.E421K	SNU-407	large intestine	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation altering degron motif	0.7022
p.E421K	TYK-nu	ovary	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation altering degron motif	0.7022
p.Q436K	H-EMC-SS	bone	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.0833
p.D435N	QIMR-WIL	haematopoietic and lymphoid tissue	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.1111
p.T419M	C2BBe1	large intestine	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	419:427	Mutation altering degron motif	0.7423

Kaplan plot for UACA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UACA

UniProt ID: Q9BZF9

Entrez ID: 55075

Protein name: Uveal autoantigen with coiled-coil domains and ankyrin repeats

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UACA in