DegronMD

Uniprot ID: Q9BZF9

Source protein: Uveal autoantigen with coiled-coil domains and ankyrin repeats

Source gene: UACA

Class: DEG_APCC_DBOX_1

Location: 419:427

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9985

ASA_SCORE: 116.2889

COIL: 0.7176

CONS_SCORE: 0.46

DSS_SCORE: 0.5087

HELIX: 0.2594

FCONS_SCORE: 1.2619

RIG_SCORE: 0.7142

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S429Y	TCGA-AP-A0LM	UCEC	TCGA	SRSMLRPLE	DEG_APCC_DBOX_1	0.2778
p.T434M	TCGA-AX-A3FT	UCEC	TCGA	SRSMLRPLE	DEG_APCC_DBOX_1	0.1389
p.T434M	SIDM01233	Colorectal Carcinoma	GDSC	SRSMLRPLE	DEG_APCC_DBOX_1	0.1389
p.T434M	C2BBe1	large_intestine	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	0.1389
p.S435P	TCGA-BR-4361	STAD	TCGA	SRSMLRPLE	DEG_APCC_DBOX_1	0.1111
p.R424I	TCGA-EO-A22R	UCEC	TCGA	SRSMLRPLE	DEG_APCC_DBOX_1	0.6991
p.R437Q	DO9114	COAD	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	0.5
p.R437Q	DO43306	UCEC	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	0.5
p.R437Q	DO223286	UCEC	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	0.5
p.R437Q	HCC2998	large_intestine	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	0.5
p.K430N	DO222762	COCA	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	0.25
p.K430N	DO49060	HNSC	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	0.25
p.L410V	DO228696	EOPC	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	0.0833
p.S422P	DO38887	STAD	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	0.6752
p.T421M	DO40801	UCEC	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	0.7423
p.T421M	C2BBe1	large_intestine	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	0.7423
p.S416Y	DO43306	UCEC	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	0.25
p.R411I	DO42713	UCEC	ICGC	SRSMLRPLE	DEG_APCC_DBOX_1	0.1111
p.R435Q	HCC2998	large_intestine	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	0.1111
p.E421K	TASK1	bone	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	0.7022
p.E421K	SNU-407	large_intestine	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	0.7022
p.E421K	TYK-nu	ovary	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	0.7022
p.Q436K	H-EMC-SS	bone	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	0.0833
p.D435N	QIMR-WIL	haematopoietic_and_lymphoid_tissue	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	0.1111
p.T419M	C2BBe1	large_intestine	COSMIC	SRSMLRPLE	DEG_APCC_DBOX_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZF9	Uveal autoantigen with coiled-coil domains and ankyrin repeats	DEG_APCC_DBOX_1	419:427	SRSMLRPLE	APC,CDC20,FZR1	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRSMLRPLE

Degron related mutations and impact score

Drug responses associated with UACA mutations

All proteins holding degron of SRSMLRPLE