DegronMD - Q9BZG8(DPH1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A253T	TCGA-2W-A8YY	CESC	TCGA	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.A253T	TCGA-AG-3891	READ	TCGA	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.A253T	TCGA-G4-6586	COAD	TCGA	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.A253T	DO223732	CESC	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.A253T	DO9698	COAD	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.A253T	DO33091	PACA	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.A253T	DO36388	READ	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.A253T	SIDM00596	Endometrial Carcinoma	GDSC	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.A253T	ACH-000941	Endometrial/Uterine Cancer	CCLE	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.A253T	ACH-000954	Endometrial/Uterine Cancer	CCLE	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.A253T	ACH-001517	Endometrial/Uterine Cancer	CCLE	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.A253T	HEC-1	endometrium	COSMIC	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.R238S	TCGA-AA-3947	COAD	TCGA	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.7427
p.R238S	DO8192	COAD	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.7427
p.R238H	TCGA-AX-A1CE	UCEC	TCGA	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.8244
p.R238H	DO232761	PBCA	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.8244
p.R238H	DO42280	UCEC	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.8244
p.A230V	TCGA-AX-A2HC	UCEC	TCGA	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1389
p.A230V	DO41572	UCEC	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1389
p.R255Q	TCGA-B5-A3FC	UCEC	TCGA	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.0556
p.R255Q	DO41871	UCEC	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.0556
p.V228L	DO224847	BRCA	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.0833
p.V228L	DO227473	BRCA	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.0833
p.G237C	DO233207	GACA	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.6489
p.G237C	DO228952	LICA	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.6489
p.P249S	DO218847	SKCA	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.2222
p.V231I	SIDM01582	Gastric Carcinoma	GDSC	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1667
p.V232E	SIDM01619	Endometrial Carcinoma	GDSC	GRFHLESVM	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1944

Kaplan plot for DPH1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DPH1

UniProt ID: Q9BZG8

Entrez ID: 1801

Protein name: 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (Ovarian cancer-associated gene 1 protein) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DPH1 in