DegronMD

Uniprot ID: Q9BZG8

Source protein: 2-

Source gene: DPH1

Class: DEG_APCC_DBOX_1

Location: 237:245

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6105

ASA_SCORE: 27.5778

COIL: 0.3484

CONS_SCORE: 0.8637

DSS_SCORE: 0.1339

HELIX: 0.4712

FCONS_SCORE: 1.2541

RIG_SCORE: 0.8403

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A253T	TCGA-2W-A8YY	CESC	TCGA	GRFHLESVM	DEG_APCC_DBOX_1	0.1111
p.A253T	TCGA-AG-3891	READ	TCGA	GRFHLESVM	DEG_APCC_DBOX_1	0.1111
p.A253T	TCGA-G4-6586	COAD	TCGA	GRFHLESVM	DEG_APCC_DBOX_1	0.1111
p.A253T	DO223732	CESC	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	0.1111
p.A253T	DO9698	COAD	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	0.1111
p.A253T	DO33091	PACA	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	0.1111
p.A253T	DO36388	READ	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	0.1111
p.A253T	SIDM00596	Endometrial Carcinoma	GDSC	GRFHLESVM	DEG_APCC_DBOX_1	0.1111
p.A253T	ACH-000941	Endometrial/Uterine Cancer	CCLE	GRFHLESVM	DEG_APCC_DBOX_1	0.1111
p.A253T	ACH-000954	Endometrial/Uterine Cancer	CCLE	GRFHLESVM	DEG_APCC_DBOX_1	0.1111
p.A253T	ACH-001517	Endometrial/Uterine Cancer	CCLE	GRFHLESVM	DEG_APCC_DBOX_1	0.1111
p.A253T	HEC-1	endometrium	COSMIC	GRFHLESVM	DEG_APCC_DBOX_1	0.1111
p.R238S	TCGA-AA-3947	COAD	TCGA	GRFHLESVM	DEG_APCC_DBOX_1	0.7427
p.R238S	DO8192	COAD	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	0.7427
p.R238H	TCGA-AX-A1CE	UCEC	TCGA	GRFHLESVM	DEG_APCC_DBOX_1	0.8244
p.R238H	DO232761	PBCA	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	0.8244
p.R238H	DO42280	UCEC	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	0.8244
p.A230V	TCGA-AX-A2HC	UCEC	TCGA	GRFHLESVM	DEG_APCC_DBOX_1	0.1389
p.A230V	DO41572	UCEC	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	0.1389
p.R255Q	TCGA-B5-A3FC	UCEC	TCGA	GRFHLESVM	DEG_APCC_DBOX_1	0.0556
p.R255Q	DO41871	UCEC	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	0.0556
p.V228L	DO224847	BRCA	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	0.0833
p.V228L	DO227473	BRCA	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	0.0833
p.G237C	DO233207	GACA	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	0.6489
p.G237C	DO228952	LICA	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	0.6489
p.P249S	DO218847	SKCA	ICGC	GRFHLESVM	DEG_APCC_DBOX_1	0.2222
p.V231I	SIDM01582	Gastric Carcinoma	GDSC	GRFHLESVM	DEG_APCC_DBOX_1	0.1667
p.V232E	SIDM01619	Endometrial Carcinoma	GDSC	GRFHLESVM	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRFHLESVM

Degron related mutations and impact score

Drug responses associated with DPH1 mutations

All proteins holding degron of GRFHLESVM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZG8	2-	DEG_APCC_DBOX_1	237:245	GRFHLESVM	APC,CDC20,FZR1	0.6105	More...