DegronMD - Q9BZW8(CD244)

FUNCTION: Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:10359122, PubMed:8376943, PubMed:11714776). Activating function implicates association with SH2D1A and FYN (PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10934222, PubMed:15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed:8376943, PubMed:11714776). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1 (PubMed:10741393). At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (PubMed:11917118). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD488 provides costimulatory-like function for neighboring T-cells (By similarity). Inhibits inflammatory responses in dendritic cells (DCs) (By similarity). {ECO:0000250|UniProtKB:Q07763, ECO:0000269|PubMed:10359122, ECO:0000269|PubMed:10741393, ECO:0000269|PubMed:10934222, ECO:0000269|PubMed:11714776, ECO:0000269|PubMed:11917118, ECO:0000269|PubMed:8376943, ECO:0000305|PubMed:15713798}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T262N	TCGA-44-2656	LUAD	TCGA	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation rewiring degron network	0.1667
p.T262N	DO26052	LUAD	ICGC	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation rewiring degron network	0.1667
p.E266A	TCGA-A5-A2K5	UCEC	TCGA	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation rewiring degron network	0.2778
p.E266A	DO41379	UCEC	ICGC	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation rewiring degron network	0.2778
p.R281I	TCGA-AA-3510	COAD	TCGA	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation rewiring degron network	0.1111
p.R281I	TCGA-DF-A2KV	UCEC	TCGA	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation rewiring degron network	0.1111
p.R281I	DO7783	COAD	ICGC	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation rewiring degron network	0.1111
p.R281I	DO219771	UCEC	ICGC	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation rewiring degron network	0.1111
p.E272K	TCGA-AP-A056	UCEC	TCGA	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation altering degron motif	0.591
p.E272K	DO43971	UCEC	ICGC	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation altering degron motif	0.591
p.D273H	TCGA-FD-A3SJ	BLCA	TCGA	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation altering degron motif	0.7688
p.D273H	DO681	BLCA	ICGC	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation altering degron motif	0.7688
p.R281K	TCGA-FR-A726	SKCM	TCGA	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation rewiring degron network	0.1111
p.R281K	DO48665	SKCM	ICGC	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation rewiring degron network	0.1111
p.L268S	TCGA-ZF-AA4W	BLCA	TCGA	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation altering degron motif	0.7667
p.L268S	DO219089	BLCA	ICGC	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation altering degron motif	0.7667
p.L277M	DO234235	ESAD	ICGC	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation rewiring degron network	0.2222
p.E266K	DO222753	MELA	ICGC	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation rewiring degron network	0.2778
p.R260Q	Sarc9371	bone	COSMIC	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation rewiring degron network	0.1111
p.R260Q	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	LTIYED	LIG_APCC_ABBA_1	268:273	Mutation rewiring degron network	0.1111

Kaplan plot for CD244 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CD244

UniProt ID: Q9BZW8

Entrez ID: 51744

Protein name: Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CD244 in