DegronMD

Uniprot ID: Q9BZW8

Source protein: Natural killer cell receptor 2B4

Source gene: CD244

Class: LIG_APCC_ABBA_1

Location: 268:273

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8819

ASA_SCORE: 70.0667

COIL: 0.4388

CONS_SCORE: 0.5197

DSS_SCORE: 0.4069

HELIX: 0.15

FCONS_SCORE: 1.5576

RIG_SCORE: 0.8671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T262N	TCGA-44-2656	LUAD	TCGA	LTIYED	LIG_APCC_ABBA_1	0.1667
p.T262N	DO26052	LUAD	ICGC	LTIYED	LIG_APCC_ABBA_1	0.1667
p.E266A	TCGA-A5-A2K5	UCEC	TCGA	LTIYED	LIG_APCC_ABBA_1	0.2778
p.E266A	DO41379	UCEC	ICGC	LTIYED	LIG_APCC_ABBA_1	0.2778
p.R281I	TCGA-AA-3510	COAD	TCGA	LTIYED	LIG_APCC_ABBA_1	0.1111
p.R281I	TCGA-DF-A2KV	UCEC	TCGA	LTIYED	LIG_APCC_ABBA_1	0.1111
p.R281I	DO7783	COAD	ICGC	LTIYED	LIG_APCC_ABBA_1	0.1111
p.R281I	DO219771	UCEC	ICGC	LTIYED	LIG_APCC_ABBA_1	0.1111
p.E272K	TCGA-AP-A056	UCEC	TCGA	LTIYED	LIG_APCC_ABBA_1	0.591
p.E272K	DO43971	UCEC	ICGC	LTIYED	LIG_APCC_ABBA_1	0.591
p.D273H	TCGA-FD-A3SJ	BLCA	TCGA	LTIYED	LIG_APCC_ABBA_1	0.7688
p.D273H	DO681	BLCA	ICGC	LTIYED	LIG_APCC_ABBA_1	0.7688
p.R281K	TCGA-FR-A726	SKCM	TCGA	LTIYED	LIG_APCC_ABBA_1	0.1111
p.R281K	DO48665	SKCM	ICGC	LTIYED	LIG_APCC_ABBA_1	0.1111
p.L268S	TCGA-ZF-AA4W	BLCA	TCGA	LTIYED	LIG_APCC_ABBA_1	0.7667
p.L268S	DO219089	BLCA	ICGC	LTIYED	LIG_APCC_ABBA_1	0.7667
p.L277M	DO234235	ESAD	ICGC	LTIYED	LIG_APCC_ABBA_1	0.2222
p.E266K	DO222753	MELA	ICGC	LTIYED	LIG_APCC_ABBA_1	0.2778
p.R260Q	Sarc9371	bone	COSMIC	LTIYED	LIG_APCC_ABBA_1	0.1111
p.R260Q	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	LTIYED	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZW8	Natural killer cell receptor 2B4	LIG_APCC_ABBA_1	268:273	LTIYED	APC,CDC20,FZR1	0.8819	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons