DegronMD - Q9C010(PKIB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N35K	TCGA-A6-2686	COAD	TCGA	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.3056
p.N35K	DO7828	COAD	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.3056
p.R33H	TCGA-A6-3808	COAD	TCGA	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.8244
p.R33H	DO8408	COAD	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.8244
p.R33H	SIDM01293	Colorectal Carcinoma	GDSC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.8244
p.R34Q	TCGA-B5-A3FC	UCEC	TCGA	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.7329
p.R34Q	TCGA-E7-A7DV	BLCA	TCGA	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.7329
p.R34Q	DO48583	BLCA	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.7329
p.R34Q	DO41871	UCEC	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.7329
p.R34Q	SIDM00615	Hepatocellular Carcinoma	GDSC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.7329
p.R34Q	JHH-6	liver	COSMIC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.7329
p.R30K	TCGA-D3-A1Q6	SKCM	TCGA	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.7237
p.R30K	TCGA-DX-A8BP	SARC	TCGA	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.7237
p.R30K	DO220056	SARC	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.7237
p.R30K	DO37450	SKCM	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.7237
p.D39G	TCGA-EO-A22R	UCEC	TCGA	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1944
p.D39G	DO42713	UCEC	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1944
p.G21E	TCGA-G4-6304	COAD	TCGA	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1944
p.G21E	DO10639	COAD	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1944
p.V18M	DO233731	GACA	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1111
p.A29S	DO229019	LICA	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.6477
p.R33L	DO229034	LICA	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.8428
p.N24I	DO45299	LIRI	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.2778
p.T16S	DO231136	LUSC	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.0556
p.A23T	DO52686	MALY	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.25
p.R27Q	ACH-000217	Liver Cancer	CCLE	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.7329
p.R27Q	JHH-6	liver	COSMIC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.7329
p.G41R	LAN-6	autonomic ganglia	COSMIC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1389
p.R36Q	JHH-6	liver	COSMIC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.2778
p.D40H	HO-1-u-1	upper aerodigestive tract	COSMIC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1667
p.T42I	KYSE-50	oesophagus	COSMIC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1111
p.D44G	NCI-H1944	lung	COSMIC	RRNALPDIQ	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.0556

Kaplan plot for PKIB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PKIB

UniProt ID: Q9C010

Entrez ID: 5570

Protein name: cAMP-dependent protein kinase inhibitor beta (PKI-beta)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PKIB in