DegronMD

Uniprot ID: Q9C010

Source protein: cAMP-dependent protein kinase inhibitor beta

Source gene: PKIB

Class: DEG_APCC_DBOX_1

Location: 26:34

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7884

ASA_SCORE: 67.7889

COIL: 0.5274

CONS_SCORE: 0.9354

DSS_SCORE: 0.5203

HELIX: 0.3247

FCONS_SCORE: 1.2678

RIG_SCORE: 0.6946

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N35K	TCGA-A6-2686	COAD	TCGA	RRNALPDIQ	DEG_APCC_DBOX_1	0.3056
p.N35K	DO7828	COAD	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	0.3056
p.R33H	TCGA-A6-3808	COAD	TCGA	RRNALPDIQ	DEG_APCC_DBOX_1	0.8244
p.R33H	DO8408	COAD	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	0.8244
p.R33H	SIDM01293	Colorectal Carcinoma	GDSC	RRNALPDIQ	DEG_APCC_DBOX_1	0.8244
p.R34Q	TCGA-B5-A3FC	UCEC	TCGA	RRNALPDIQ	DEG_APCC_DBOX_1	0.7329
p.R34Q	TCGA-E7-A7DV	BLCA	TCGA	RRNALPDIQ	DEG_APCC_DBOX_1	0.7329
p.R34Q	DO48583	BLCA	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	0.7329
p.R34Q	DO41871	UCEC	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	0.7329
p.R34Q	SIDM00615	Hepatocellular Carcinoma	GDSC	RRNALPDIQ	DEG_APCC_DBOX_1	0.7329
p.R34Q	JHH-6	liver	COSMIC	RRNALPDIQ	DEG_APCC_DBOX_1	0.7329
p.R30K	TCGA-D3-A1Q6	SKCM	TCGA	RRNALPDIQ	DEG_APCC_DBOX_1	0.7237
p.R30K	TCGA-DX-A8BP	SARC	TCGA	RRNALPDIQ	DEG_APCC_DBOX_1	0.7237
p.R30K	DO220056	SARC	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	0.7237
p.R30K	DO37450	SKCM	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	0.7237
p.D39G	TCGA-EO-A22R	UCEC	TCGA	RRNALPDIQ	DEG_APCC_DBOX_1	0.1944
p.D39G	DO42713	UCEC	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	0.1944
p.G21E	TCGA-G4-6304	COAD	TCGA	RRNALPDIQ	DEG_APCC_DBOX_1	0.1944
p.G21E	DO10639	COAD	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	0.1944
p.V18M	DO233731	GACA	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	0.1111
p.A29S	DO229019	LICA	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	0.6477
p.R33L	DO229034	LICA	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	0.8428
p.N24I	DO45299	LIRI	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	0.2778
p.T16S	DO231136	LUSC	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	0.0556
p.A23T	DO52686	MALY	ICGC	RRNALPDIQ	DEG_APCC_DBOX_1	0.25
p.R27Q	ACH-000217	Liver Cancer	CCLE	RRNALPDIQ	DEG_APCC_DBOX_1	0.7329
p.R27Q	JHH-6	liver	COSMIC	RRNALPDIQ	DEG_APCC_DBOX_1	0.7329
p.G41R	LAN-6	autonomic_ganglia	COSMIC	RRNALPDIQ	DEG_APCC_DBOX_1	0.1389
p.R36Q	JHH-6	liver	COSMIC	RRNALPDIQ	DEG_APCC_DBOX_1	0.2778
p.D40H	HO-1-u-1	upper_aerodigestive_tract	COSMIC	RRNALPDIQ	DEG_APCC_DBOX_1	0.1667
p.T42I	KYSE-50	oesophagus	COSMIC	RRNALPDIQ	DEG_APCC_DBOX_1	0.1111
p.D44G	NCI-H1944	lung	COSMIC	RRNALPDIQ	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRNALPDIQ

Degron related mutations and impact score

Drug responses associated with PKIB mutations

All proteins holding degron of RRNALPDIQ

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C010	cAMP-dependent protein kinase inhibitor beta	DEG_APCC_DBOX_1	26:34	RRNALPDIQ	APC,CDC20,FZR1	0.7884	More...