DegronMD - Q9C075(KRT23)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E213D	TCGA-A5-A0G1	UCEC	TCGA	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.1667
p.E202Q	TCGA-AC-A23H	BRCA	TCGA	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation altering degron motif	0.5633
p.E215Q	TCGA-K4-A83P	BLCA	TCGA	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.1111
p.E193Q	TCGA-QK-A64Z	HNSC	TCGA	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.1667
p.T204M	DO8514	COAD	ICGC	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation altering degron motif	0.7423
p.T204M	DO233764	GACA	ICGC	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation altering degron motif	0.7423
p.R212W	DO234205	ESAD	ICGC	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.1944
p.R212W	DO49204	PACA	ICGC	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.1944
p.R212Q	DO233291	GACA	ICGC	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.1944
p.R207C	DO13605	GBM	ICGC	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation altering degron motif	0.8301
p.R207C	DO40978	UCEC	ICGC	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation altering degron motif	0.8301
p.H198N	DO23624	LUAD	ICGC	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.E216K	DO229456	SKCA	ICGC	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation substituting flanking lysine	0.1944
p.Y217C	DO229208	THCA	ICGC	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.0556
p.L206P	DO229232	THCA	ICGC	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation altering degron motif	0.7582
p.E194D	DO41752	UCEC	ICGC	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.1944
p.M192I	DO42673	UCEC	ICGC	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.1389
p.H217L	SIDM00175	Melanoma	GDSC	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.0556
p.H217L	ACH-002096	Skin Cancer	CCLE	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.0556
p.H217L	CP50-MEL-B	skin	COSMIC	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.0556
p.E193K	ACH-001541	Myeloma	CCLE	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.1667
p.E195D	ACH-001610	Brain Cancer	CCLE	MRKELILMK	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.2222

Kaplan plot for KRT23 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRT23

UniProt ID: Q9C075

Entrez ID: 25984

Protein name: Keratin, type I cytoskeletal 23 (Cytokeratin-23) (CK-23) (Keratin-23) (K23)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRT23 in