DegronMD

Uniprot ID: Q9C075

Source protein: Keratin, type I cytoskeletal 23

Source gene: KRT23

Class: DEG_APCC_DBOX_1

Location: 199:207

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8586

ASA_SCORE: 80.6111

COIL: 0.0113

CONS_SCORE: 0.7568

DSS_SCORE: 0.4518

HELIX: 0.9886

FCONS_SCORE: 1.0617

RIG_SCORE: 0.8064

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E213D	TCGA-A5-A0G1	UCEC	TCGA	MRKELILMK	DEG_APCC_DBOX_1	0.1667
p.E202Q	TCGA-AC-A23H	BRCA	TCGA	MRKELILMK	DEG_APCC_DBOX_1	0.5633
p.E215Q	TCGA-K4-A83P	BLCA	TCGA	MRKELILMK	DEG_APCC_DBOX_1	0.1111
p.E193Q	TCGA-QK-A64Z	HNSC	TCGA	MRKELILMK	DEG_APCC_DBOX_1	0.1667
p.T204M	DO8514	COAD	ICGC	MRKELILMK	DEG_APCC_DBOX_1	0.7423
p.T204M	DO233764	GACA	ICGC	MRKELILMK	DEG_APCC_DBOX_1	0.7423
p.R212W	DO234205	ESAD	ICGC	MRKELILMK	DEG_APCC_DBOX_1	0.1944
p.R212W	DO49204	PACA	ICGC	MRKELILMK	DEG_APCC_DBOX_1	0.1944
p.R212Q	DO233291	GACA	ICGC	MRKELILMK	DEG_APCC_DBOX_1	0.1944
p.R207C	DO13605	GBM	ICGC	MRKELILMK	DEG_APCC_DBOX_1	0.8301
p.R207C	DO40978	UCEC	ICGC	MRKELILMK	DEG_APCC_DBOX_1	0.8301
p.H198N	DO23624	LUAD	ICGC	MRKELILMK	DEG_APCC_DBOX_1	0.3056
p.E216K	DO229456	SKCA	ICGC	MRKELILMK	DEG_APCC_DBOX_1	0.1944
p.Y217C	DO229208	THCA	ICGC	MRKELILMK	DEG_APCC_DBOX_1	0.0556
p.L206P	DO229232	THCA	ICGC	MRKELILMK	DEG_APCC_DBOX_1	0.7582
p.E194D	DO41752	UCEC	ICGC	MRKELILMK	DEG_APCC_DBOX_1	0.1944
p.M192I	DO42673	UCEC	ICGC	MRKELILMK	DEG_APCC_DBOX_1	0.1389
p.H217L	SIDM00175	Melanoma	GDSC	MRKELILMK	DEG_APCC_DBOX_1	0.0556
p.H217L	ACH-002096	Skin Cancer	CCLE	MRKELILMK	DEG_APCC_DBOX_1	0.0556
p.H217L	CP50-MEL-B	skin	COSMIC	MRKELILMK	DEG_APCC_DBOX_1	0.0556
p.E193K	ACH-001541	Myeloma	CCLE	MRKELILMK	DEG_APCC_DBOX_1	0.1667
p.E195D	ACH-001610	Brain Cancer	CCLE	MRKELILMK	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C075	Keratin, type I cytoskeletal 23	DEG_APCC_DBOX_1	199:207	MRKELILMK	APC,CDC20,FZR1	0.8586	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons