DegronMD - Q9C0I1(MTMR12)

MTMR12

UniProt ID: Q9C0I1

Entrez ID: 54545

Protein name: Myotubularin-related protein 12 (Inactive phosphatidylinositol 3-phosphatase 12) (Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit) (3-PAP) (3-phosphatase adapter protein)

External links: UniprotKB HGNC RefSeq COSMIC

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GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E529K	TCGA-44-7667	LUAD	TCGA	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.1111
p.E529K	DO23830	LUAD	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.1111
p.Q527P	TCGA-A8-A07G	BRCA	TCGA	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.0556
p.Q527P	DO2870	BRCA	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.0556
p.L547M	TCGA-AG-3892	READ	TCGA	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.2222
p.L547M	DO229038	LICA	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.2222
p.L547M	DO36394	READ	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.2222
p.Q533H	TCGA-AP-A1DV	UCEC	TCGA	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.2222
p.Q533H	DO43186	UCEC	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.2222
p.P530R	DO52544	BRCA	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.1389
p.L536F	DO223562	CLLE	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.3056
p.R540I	DO7783	COAD	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation altering degron motif	0.8102
p.R540I	DO43041	UCEC	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation altering degron motif	0.8102
p.R540I	HCC2998	large intestine	COSMIC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation altering degron motif	0.8102
p.S547Y	DO8264	COAD	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.2222
p.I537S	DO10880	GBM	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation altering degron motif	0.7341
p.D549H	DO15791	HNSC	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation substituting flanking lysine	0.2778
p.Q551K	DO229027	LICA	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.1111
p.T529K	DO229032	LICA	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.1111
p.T550A	DO49715	LIHC	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.1389
p.G544C	DO230538	LUSC	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation blocking ubiquitination signal	0.75
p.E527K	DO34048	PACA	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.0556
p.R535C	DO51407	PRAD	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.2778
p.L544F	DO42280	UCEC	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation blocking ubiquitination signal	0.75
p.I542T	DO41584	UCEC	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation altering degron motif	0.7078
p.S547F	DO43755	UCEC	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.2222
p.R552W	SIDM00214	Colorectal Carcinoma	GDSC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.0833
p.R552W	SNU-407	large intestine	COSMIC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.0833
p.L551V	KYSE-450	oesophagus	COSMIC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.1111
p.E527G	SNU-1040	large intestine	COSMIC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	537:543	Mutation rewiring degron network	0.0556

Kaplan plot for MTMR12 in

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*NOTE: the Kaplan plots were collected from OncoLnc