DegronMD

Uniprot ID: Q9C0I1

Source protein: Myotubularin-related protein 12

Source gene: MTMR12

Class: LIG_APCC_ABBAyCdc20_2

Location: 537:543

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9816

ASA_SCORE: 50.9143

COIL: 0.8049

CONS_SCORE: 0.6539

DSS_SCORE: 0.4079

HELIX: 0.0479

FCONS_SCORE: 1.3779

RIG_SCORE: 0.8179

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E529K	TCGA-44-7667	LUAD	TCGA	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E529K	DO23830	LUAD	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q527P	TCGA-A8-A07G	BRCA	TCGA	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.0556
p.Q527P	DO2870	BRCA	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.0556
p.L547M	TCGA-AG-3892	READ	TCGA	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.2222
p.L547M	DO229038	LICA	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.2222
p.L547M	DO36394	READ	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.2222
p.Q533H	TCGA-AP-A1DV	UCEC	TCGA	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.2222
p.Q533H	DO43186	UCEC	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P530R	DO52544	BRCA	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.1389
p.L536F	DO223562	CLLE	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R540I	DO7783	COAD	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R540I	DO43041	UCEC	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R540I	HCC2998	large_intestine	COSMIC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.8102
p.S547Y	DO8264	COAD	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.2222
p.I537S	DO10880	GBM	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.7341
p.D549H	DO15791	HNSC	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.2778
p.Q551K	DO229027	LICA	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.1111
p.T529K	DO229032	LICA	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.1111
p.T550A	DO49715	LIHC	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G544C	DO230538	LUSC	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.75
p.E527K	DO34048	PACA	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R535C	DO51407	PRAD	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.2778
p.L544F	DO42280	UCEC	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.75
p.I542T	DO41584	UCEC	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.7078
p.S547F	DO43755	UCEC	ICGC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R552W	SIDM00214	Colorectal Carcinoma	GDSC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R552W	SNU-407	large_intestine	COSMIC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.0833
p.L551V	KYSE-450	oesophagus	COSMIC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E527G	SNU-1040	large_intestine	COSMIC	KNPLYVE	LIG_APCC_ABBAyCdc20_2	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KNPLYVE

Degron related mutations and impact score

Drug responses associated with MTMR12 mutations

All proteins holding degron of KNPLYVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0I1	Myotubularin-related protein 12	LIG_APCC_ABBAyCdc20_2	537:543	KNPLYVE	APC,CDC20,FZR1	0.9816	More...