DegronMD - Q9GZL7(WDR12)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L253V	TCGA-A6-5659	COAD	TCGA	LTRTPIVT	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.3056
p.L253V	DO9860	COAD	ICGC	LTRTPIVT	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.3056
p.T240K	DO228986	LICA	ICGC	LTRTPIVT	DEG_SCF_FBW7_1	245:252	Mutation rewiring degron network	0.1944
p.R247M	DO229211	THCA	ICGC	LTRTPIVT	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.7521
p.V251G	SIDM00924	Other Solid Cancers	GDSC	LTRTPIVT	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.6421
p.V251G	ACH-000867	Lung Cancer	CCLE	LTRTPIVT	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.6421
p.V251G	ChaGo-K-1	lung	COSMIC	LTRTPIVT	DEG_SCF_FBW7_1	245:252	Mutation altering degron motif	0.6421

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons