DegronMD

Uniprot ID: Q9GZL7

Source protein: Ribosome biogenesis protein WDR12

Source gene: WDR12

Class: DEG_SCF_FBW7_1

Location: 245:252

E3 ligase: FBXW7

DEGRON score: 0.5835

ASA_SCORE: 69.6125

COIL: 0.4733

CONS_SCORE: 0.6869

DSS_SCORE: 0.4755

HELIX: 0.0487

FCONS_SCORE: 0.9664

RIG_SCORE: 0.789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L253V	TCGA-A6-5659	COAD	TCGA	LTRTPIVT	DEG_SCF_FBW7_1	0.3056
p.L253V	DO9860	COAD	ICGC	LTRTPIVT	DEG_SCF_FBW7_1	0.3056
p.T240K	DO228986	LICA	ICGC	LTRTPIVT	DEG_SCF_FBW7_1	0.1944
p.R247M	DO229211	THCA	ICGC	LTRTPIVT	DEG_SCF_FBW7_1	0.7521
p.V251G	SIDM00924	Other Solid Cancers	GDSC	LTRTPIVT	DEG_SCF_FBW7_1	0.6421
p.V251G	ACH-000867	Lung Cancer	CCLE	LTRTPIVT	DEG_SCF_FBW7_1	0.6421
p.V251G	ChaGo-K-1	lung	COSMIC	LTRTPIVT	DEG_SCF_FBW7_1	0.6421

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9GZL7	Ribosome biogenesis protein WDR12	DEG_SCF_FBW7_1	245:252	LTRTPIVT	FBXW7	0.5835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons