DegronMD - Q9GZP1(NRSN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P150L	TCGA-39-5022	LUSC	TCGA	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.0833
p.P150L	DO27604	LUSC	ICGC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.0833
p.D156N	TCGA-AJ-A3EL	UCEC	TCGA	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.25
p.D156N	DO41542	UCEC	ICGC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.25
p.E154K	TCGA-C4-A0EZ	BLCA	TCGA	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.1944
p.E154K	DO476	BLCA	ICGC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.1944
p.E160D	TCGA-D1-A103	UCEC	TCGA	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation altering degron motif	0.5647
p.E160D	DO222421	BTCA	ICGC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation altering degron motif	0.5647
p.E160D	DO42312	UCEC	ICGC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation altering degron motif	0.5647
p.E149D	TCGA-X6-A7WB	SARC	TCGA	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.0556
p.E149D	DO220314	SARC	ICGC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.0556
p.P172L	TCGA-Z2-A8RT	SKCM	TCGA	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.1111
p.P172L	DO51301	SKCM	ICGC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.1111
p.G163R	DO228403	MALY	ICGC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation altering degron motif	0.6457
p.G163R	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation altering degron motif	0.6457
p.G163R	A549	lung	COSMIC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation altering degron motif	0.6457
p.E160Q	SIDM01265	Plasma Cell Myeloma	GDSC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation altering degron motif	0.5633
p.E160Q	SIDM01112	Osteosarcoma	GDSC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation altering degron motif	0.5633
p.E160Q	SIDM00257	Neuroblastoma	GDSC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation altering degron motif	0.5633
p.E160Q	SIDM00760	Small Cell Lung Carcinoma	GDSC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation altering degron motif	0.5633
p.E160Q	SIDM01664	Prostate Carcinoma	GDSC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation altering degron motif	0.5633
p.E160Q	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation altering degron motif	0.5633
p.E160Q	SIDM01525	Acute Myeloid Leukemia	GDSC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation altering degron motif	0.5633
p.P150S	SIDM00516	Melanoma	GDSC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.0833
p.P150S	ACH-002166	Skin Cancer	CCLE	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.0833
p.P150S	MZ7-mel	skin	COSMIC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.0833
p.Q168R	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.2222
p.Q168R	NCI-H1435	lung	COSMIC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.2222
p.P166T	SIDM01228	Melanoma	GDSC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.2778
p.P166T	ACH-001024	Skin Cancer	CCLE	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.2778
p.P166T	CHL-1	skin	COSMIC	VEVFGD	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NRSN2

UniProt ID: Q9GZP1

Entrez ID: 80023

Protein name: Neurensin-2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NRSN2 in