DegronMD

Uniprot ID: Q9GZP1

Source protein: Neurensin-2

Source gene: NRSN2

Class: LIG_APCC_ABBA_1

Location: 159:164

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6989

ASA_SCORE: 70.15

COIL: 0.593

CONS_SCORE: 0.6025

DSS_SCORE: 0.6485

HELIX: 0.0595

FCONS_SCORE: 0.8704

RIG_SCORE: 0.7397

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P150L	TCGA-39-5022	LUSC	TCGA	VEVFGD	LIG_APCC_ABBA_1	0.0833
p.P150L	DO27604	LUSC	ICGC	VEVFGD	LIG_APCC_ABBA_1	0.0833
p.D156N	TCGA-AJ-A3EL	UCEC	TCGA	VEVFGD	LIG_APCC_ABBA_1	0.25
p.D156N	DO41542	UCEC	ICGC	VEVFGD	LIG_APCC_ABBA_1	0.25
p.E154K	TCGA-C4-A0EZ	BLCA	TCGA	VEVFGD	LIG_APCC_ABBA_1	0.1944
p.E154K	DO476	BLCA	ICGC	VEVFGD	LIG_APCC_ABBA_1	0.1944
p.E160D	TCGA-D1-A103	UCEC	TCGA	VEVFGD	LIG_APCC_ABBA_1	0.5647
p.E160D	DO222421	BTCA	ICGC	VEVFGD	LIG_APCC_ABBA_1	0.5647
p.E160D	DO42312	UCEC	ICGC	VEVFGD	LIG_APCC_ABBA_1	0.5647
p.E149D	TCGA-X6-A7WB	SARC	TCGA	VEVFGD	LIG_APCC_ABBA_1	0.0556
p.E149D	DO220314	SARC	ICGC	VEVFGD	LIG_APCC_ABBA_1	0.0556
p.P172L	TCGA-Z2-A8RT	SKCM	TCGA	VEVFGD	LIG_APCC_ABBA_1	0.1111
p.P172L	DO51301	SKCM	ICGC	VEVFGD	LIG_APCC_ABBA_1	0.1111
p.G163R	DO228403	MALY	ICGC	VEVFGD	LIG_APCC_ABBA_1	0.6457
p.G163R	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	VEVFGD	LIG_APCC_ABBA_1	0.6457
p.G163R	A549	lung	COSMIC	VEVFGD	LIG_APCC_ABBA_1	0.6457
p.E160Q	SIDM01265	Plasma Cell Myeloma	GDSC	VEVFGD	LIG_APCC_ABBA_1	0.5633
p.E160Q	SIDM01112	Osteosarcoma	GDSC	VEVFGD	LIG_APCC_ABBA_1	0.5633
p.E160Q	SIDM00257	Neuroblastoma	GDSC	VEVFGD	LIG_APCC_ABBA_1	0.5633
p.E160Q	SIDM00760	Small Cell Lung Carcinoma	GDSC	VEVFGD	LIG_APCC_ABBA_1	0.5633
p.E160Q	SIDM01664	Prostate Carcinoma	GDSC	VEVFGD	LIG_APCC_ABBA_1	0.5633
p.E160Q	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	VEVFGD	LIG_APCC_ABBA_1	0.5633
p.E160Q	SIDM01525	Acute Myeloid Leukemia	GDSC	VEVFGD	LIG_APCC_ABBA_1	0.5633
p.P150S	SIDM00516	Melanoma	GDSC	VEVFGD	LIG_APCC_ABBA_1	0.0833
p.P150S	ACH-002166	Skin Cancer	CCLE	VEVFGD	LIG_APCC_ABBA_1	0.0833
p.P150S	MZ7-mel	skin	COSMIC	VEVFGD	LIG_APCC_ABBA_1	0.0833
p.Q168R	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	VEVFGD	LIG_APCC_ABBA_1	0.2222
p.Q168R	NCI-H1435	lung	COSMIC	VEVFGD	LIG_APCC_ABBA_1	0.2222
p.P166T	SIDM01228	Melanoma	GDSC	VEVFGD	LIG_APCC_ABBA_1	0.2778
p.P166T	ACH-001024	Skin Cancer	CCLE	VEVFGD	LIG_APCC_ABBA_1	0.2778
p.P166T	CHL-1	skin	COSMIC	VEVFGD	LIG_APCC_ABBA_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VEVFGD

Degron related mutations and impact score

Drug responses associated with NRSN2 mutations

All proteins holding degron of VEVFGD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9GZP1	Neurensin-2	LIG_APCC_ABBA_1	159:164	VEVFGD	APC,CDC20,FZR1	0.6989	More...