DegronMD - Q9GZX9(TWSG1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E69Q	TCGA-17-Z045	LUAD	TCGA	NPRNYSDTP	CBL_PTK	78:86	Mutation rewiring degron network	0.0833
p.M76V	TCGA-2W-A8YY	CESC	TCGA	NPRNYSDTP	CBL_PTK	78:86	Mutation rewiring degron network	0.2778
p.M76V	DO223732	CESC	ICGC	NPRNYSDTP	CBL_PTK	78:86	Mutation rewiring degron network	0.2778
p.V93A	TCGA-AX-A2HD	UCEC	TCGA	NPRNYSDTP	CBL_PTK	78:86	Mutation rewiring degron network	0.1389
p.V93A	DO42608	UCEC	ICGC	NPRNYSDTP	CBL_PTK	78:86	Mutation rewiring degron network	0.1389
p.D84V	TCGA-AZ-6598	COAD	TCGA	NPRNYSDTP	CBL_PTK	78:86	Mutation altering degron motif	0.6674
p.D84V	DO10276	COAD	ICGC	NPRNYSDTP	CBL_PTK	78:86	Mutation altering degron motif	0.6674
p.E94K	TCGA-B6-A0RE	BRCA	TCGA	NPRNYSDTP	CBL_PTK	78:86	Mutation rewiring degron network	0.1111
p.E94K	DO3482	BRCA	ICGC	NPRNYSDTP	CBL_PTK	78:86	Mutation rewiring degron network	0.1111
p.R80Q	TCGA-E6-A1M0	UCEC	TCGA	NPRNYSDTP	CBL_PTK	78:86	Mutation altering degron motif	0.6218
p.R80Q	DO43682	UCEC	ICGC	NPRNYSDTP	CBL_PTK	78:86	Mutation altering degron motif	0.6218
p.P79S	TCGA-FW-A3R5	SKCM	TCGA	NPRNYSDTP	CBL_PTK	78:86	Mutation altering degron motif	0.5641
p.P79S	DO37406	SKCM	ICGC	NPRNYSDTP	CBL_PTK	78:86	Mutation altering degron motif	0.5641
p.E69D	DO228948	LICA	ICGC	NPRNYSDTP	CBL_PTK	78:86	Mutation rewiring degron network	0.0833
p.M76I	DO228978	LICA	ICGC	NPRNYSDTP	CBL_PTK	78:86	Mutation rewiring degron network	0.2778
p.C73F	DO228985	LICA	ICGC	NPRNYSDTP	CBL_PTK	78:86	Mutation rewiring degron network	0.1944
p.C73F	DO229026	LICA	ICGC	NPRNYSDTP	CBL_PTK	78:86	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons