DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NPRNYSDTP
Uniprot ID:
Q9GZX9
Source protein:
Twisted gastrulation protein homolog 1
Source gene:
TWSG1
Class:
CBL_PTK
Location:
78:86
E3 ligase:
CBL
DEGRON score:
0.5619
ASA_SCORE:
95.1778
COIL:
0.9171
CONS_SCORE:
0.6437
DSS_SCORE:
0.1291
HELIX:
0.0473
FCONS_SCORE:
0.874
RIG_SCORE:
0.7067
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E69Q
TCGA-17-Z045
LUAD
TCGA
NPRNYSDTP
CBL_PTK
0.0833
p.M76V
TCGA-2W-A8YY
CESC
TCGA
NPRNYSDTP
CBL_PTK
0.2778
p.M76V
DO223732
CESC
ICGC
NPRNYSDTP
CBL_PTK
0.2778
p.V93A
TCGA-AX-A2HD
UCEC
TCGA
NPRNYSDTP
CBL_PTK
0.1389
p.V93A
DO42608
UCEC
ICGC
NPRNYSDTP
CBL_PTK
0.1389
p.D84V
TCGA-AZ-6598
COAD
TCGA
NPRNYSDTP
CBL_PTK
0.6674
p.D84V
DO10276
COAD
ICGC
NPRNYSDTP
CBL_PTK
0.6674
p.E94K
TCGA-B6-A0RE
BRCA
TCGA
NPRNYSDTP
CBL_PTK
0.1111
p.E94K
DO3482
BRCA
ICGC
NPRNYSDTP
CBL_PTK
0.1111
p.R80Q
TCGA-E6-A1M0
UCEC
TCGA
NPRNYSDTP
CBL_PTK
0.6218
p.R80Q
DO43682
UCEC
ICGC
NPRNYSDTP
CBL_PTK
0.6218
p.P79S
TCGA-FW-A3R5
SKCM
TCGA
NPRNYSDTP
CBL_PTK
0.5641
p.P79S
DO37406
SKCM
ICGC
NPRNYSDTP
CBL_PTK
0.5641
p.E69D
DO228948
LICA
ICGC
NPRNYSDTP
CBL_PTK
0.0833
p.M76I
DO228978
LICA
ICGC
NPRNYSDTP
CBL_PTK
0.2778
p.C73F
DO228985
LICA
ICGC
NPRNYSDTP
CBL_PTK
0.1944
p.C73F
DO229026
LICA
ICGC
NPRNYSDTP
CBL_PTK
0.1944
Drug responses associated with TWSG1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NPRNYSDTP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9GZX9
Twisted gastrulation protein homolog 1
CBL_PTK
78:86
NPRNYSDTP
CBL
0.5619
More...
