DegronMD - Q9GZY8(MFF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R149K	TCGA-29-1705	OV	TCGA	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.1389
p.E143K	TCGA-93-8067	LUAD	TCGA	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.3056
p.L130M	TCGA-A5-A0G2	UCEC	TCGA	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.1944
p.L130V	TCGA-AX-A06F	UCEC	TCGA	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.1944
p.D131N	TCGA-D9-A6EC	SKCM	TCGA	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.2222
p.P139L	TCGA-DD-AACA	LIHC	TCGA	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation altering degron motif	0.7582
p.P136L	TCGA-EO-A22U	UCEC	TCGA	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation altering degron motif	0.6471
p.R125I	TCGA-GN-A26C	SKCM	TCGA	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.0556
p.R152T	TCGA-GV-A3JZ	BLCA	TCGA	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.0556
p.R136S	DO223588	BLCA	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation altering degron motif	0.7427
p.R126T	DO773	BLCA	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.0833
p.A134V	DO22237	LGG	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.3056
p.G139V	DO228974	LICA	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation altering degron motif	0.7532
p.P148H	DO50864	LICA	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.1667
p.G152A	DO31779	OV	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.0556
p.R128W	DO51407	PRAD	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.1389
p.R128W	DO223286	UCEC	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.1389
p.R128W	ACH-000962	Ovarian Cancer	CCLE	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.1389
p.R128W	ACH-001145	Ovarian Cancer	CCLE	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.1389
p.R128W	OC-314	ovary	COSMIC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.1389
p.S146Y	DO36556	READ	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.2222
p.S146Y	DO42312	UCEC	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.2222
p.S146Y	DO41644	UCEC	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.2222
p.R151C	DO42033	UCEC	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation substituting flanking lysine	0.1944
p.A134D	DO41644	UCEC	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.3056
p.A134D	DO41361	UCEC	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.3056
p.R128Q	DO43899	UCEC	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.1389
p.R136C	DO41109	UCEC	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation altering degron motif	0.8301
p.E132K	ACH-000270	Pancreatic Cancer	CCLE	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.25
p.E132K	ACH-001098	Pancreatic Cancer	CCLE	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.25
p.E132K	ACH-001416	Bladder Cancer	CCLE	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.25
p.E132K	HPAC	pancreas	COSMIC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.25
p.L150F	NCI-H650	lung	COSMIC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.1111
p.D146N	EJM	haematopoietic and lymphoid tissue	COSMIC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation rewiring degron network	0.2222
p.Q140K	NCI-H64	lung	COSMIC	PPTTPQNE	DEG_SCF_FBW7_2	135:142	Mutation altering degron motif	0.5833

Kaplan plot for MFF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MFF

UniProt ID: Q9GZY8

Entrez ID: 56947

Protein name: Mitochondrial fission factor

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MFF in