DegronMD

Uniprot ID: Q9GZY8

Source protein: Mitochondrial fission factor

Source gene: MFF

Class: DEG_SCF_FBW7_2

Location: 135:142

E3 ligase: FBXW7

DEGRON score: 0.9098

ASA_SCORE: 87.45

COIL: 0.7683

CONS_SCORE: 0.3987

DSS_SCORE: 0.5594

HELIX: 0.2165

FCONS_SCORE: 0.7293

RIG_SCORE: 0.6754

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R149K	TCGA-29-1705	OV	TCGA	PPTTPQNE	DEG_SCF_FBW7_2	0.1389
p.E143K	TCGA-93-8067	LUAD	TCGA	PPTTPQNE	DEG_SCF_FBW7_2	0.3056
p.L130M	TCGA-A5-A0G2	UCEC	TCGA	PPTTPQNE	DEG_SCF_FBW7_2	0.1944
p.L130V	TCGA-AX-A06F	UCEC	TCGA	PPTTPQNE	DEG_SCF_FBW7_2	0.1944
p.D131N	TCGA-D9-A6EC	SKCM	TCGA	PPTTPQNE	DEG_SCF_FBW7_2	0.2222
p.P139L	TCGA-DD-AACA	LIHC	TCGA	PPTTPQNE	DEG_SCF_FBW7_2	0.7582
p.P136L	TCGA-EO-A22U	UCEC	TCGA	PPTTPQNE	DEG_SCF_FBW7_2	0.6471
p.R125I	TCGA-GN-A26C	SKCM	TCGA	PPTTPQNE	DEG_SCF_FBW7_2	0.0556
p.R152T	TCGA-GV-A3JZ	BLCA	TCGA	PPTTPQNE	DEG_SCF_FBW7_2	0.0556
p.R136S	DO223588	BLCA	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	0.7427
p.R126T	DO773	BLCA	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	0.0833
p.A134V	DO22237	LGG	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	0.3056
p.G139V	DO228974	LICA	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	0.7532
p.P148H	DO50864	LICA	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	0.1667
p.G152A	DO31779	OV	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	0.0556
p.R128W	DO51407	PRAD	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	0.1389
p.R128W	DO223286	UCEC	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	0.1389
p.R128W	ACH-000962	Ovarian Cancer	CCLE	PPTTPQNE	DEG_SCF_FBW7_2	0.1389
p.R128W	ACH-001145	Ovarian Cancer	CCLE	PPTTPQNE	DEG_SCF_FBW7_2	0.1389
p.R128W	OC-314	ovary	COSMIC	PPTTPQNE	DEG_SCF_FBW7_2	0.1389
p.S146Y	DO36556	READ	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	0.2222
p.S146Y	DO42312	UCEC	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	0.2222
p.S146Y	DO41644	UCEC	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	0.2222
p.R151C	DO42033	UCEC	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	0.1944
p.A134D	DO41644	UCEC	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	0.3056
p.A134D	DO41361	UCEC	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	0.3056
p.R128Q	DO43899	UCEC	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	0.1389
p.R136C	DO41109	UCEC	ICGC	PPTTPQNE	DEG_SCF_FBW7_2	0.8301
p.E132K	ACH-000270	Pancreatic Cancer	CCLE	PPTTPQNE	DEG_SCF_FBW7_2	0.25
p.E132K	ACH-001098	Pancreatic Cancer	CCLE	PPTTPQNE	DEG_SCF_FBW7_2	0.25
p.E132K	ACH-001416	Bladder Cancer	CCLE	PPTTPQNE	DEG_SCF_FBW7_2	0.25
p.E132K	HPAC	pancreas	COSMIC	PPTTPQNE	DEG_SCF_FBW7_2	0.25
p.L150F	NCI-H650	lung	COSMIC	PPTTPQNE	DEG_SCF_FBW7_2	0.1111
p.D146N	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	PPTTPQNE	DEG_SCF_FBW7_2	0.2222
p.Q140K	NCI-H64	lung	COSMIC	PPTTPQNE	DEG_SCF_FBW7_2	0.5833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTTPQNE

Degron related mutations and impact score

Drug responses associated with MFF mutations

All proteins holding degron of PPTTPQNE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9GZY8	Mitochondrial fission factor	DEG_SCF_FBW7_2	135:142	PPTTPQNE	FBXW7	0.9098	More...