DegronMD - Q9GZZ8(LACRT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N82S	TCGA-CN-A63Y	HNSC	TCGA	SRQELNPLK	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.5958
p.N82S	DO44422	HNSC	ICGC	SRQELNPLK	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.5958
p.E89K	TCGA-D3-A2JN	SKCM	TCGA	SRQELNPLK	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.2222
p.E89K	DO47590	SKCM	ICGC	SRQELNPLK	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.2222
p.L84M	TCGA-EE-A2MM	SKCM	TCGA	SRQELNPLK	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.5999
p.L84M	DO37770	SKCM	ICGC	SRQELNPLK	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.5999
p.E89D	TCGA-OR-A5JA	ACC	TCGA	SRQELNPLK	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.2222
p.E89Q	TCGA-UF-A7JS	HNSC	TCGA	SRQELNPLK	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.2222
p.E89Q	DO52119	HNSC	ICGC	SRQELNPLK	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.2222
p.A72T	DO233638	GACA	ICGC	SRQELNPLK	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.1944
p.L84Q	DO228299	LICA	ICGC	SRQELNPLK	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.7765
p.V88M	SIDM00473	Oral Cavity Carcinoma	GDSC	SRQELNPLK	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.25
p.V88M	ACH-000619	Head and Neck Cancer	CCLE	SRQELNPLK	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.25
p.V88M	PE/CA-PJ15	upper aerodigestive tract	COSMIC	SRQELNPLK	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.25
p.S86T	SIDM00878	Breast Carcinoma	GDSC	SRQELNPLK	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.3056
p.S86T	ACH-000930	Breast Cancer	CCLE	SRQELNPLK	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.3056
p.S86T	HCC1569	breast	COSMIC	SRQELNPLK	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.3056
p.A87V	KM12	large intestine	COSMIC	SRQELNPLK	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.2778

Kaplan plot for LACRT in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LACRT

UniProt ID: Q9GZZ8

Entrez ID: 90070

Protein name: Extracellular glycoprotein lacritin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LACRT in